Literature DB >> 6205222

Epitopes of bovine leukemia virus glycoprotein gp51 recognized by sera of infected cattle and sheep.

C Bruck, D Portetelle, M Mammerickx, S Mathot, A Burny.   

Abstract

Sera of BLV-infected cattle and sheep are tested for their reactivity with different gp51 subregions by competition with radiolabeled monoclonal antibodies directed against 8 different gp51 epitopes. Sheep antisera are found to be very polyvalent, since they are able to displace the fixation of any of the mouse monoclonal antibodies to gp51. Bovine antisera do not display significant competition with monoclonal antibodies direct against 5 out of 8 gp51 epitopes. The bovine antibody response to gp51 is focused to a limited subregion of this molecule, bearing 3 epitopes (F, G and H) recognized by antibodies with virus-neutralizing activity. The differential reactivity of cattle and sheep antisera to BLV gp51 is discussed in relation to the pathology of BLV infection in these two species.

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Year:  1984        PMID： 6205222     DOI： 10.1016/0145-2126(84)90070-5

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  7 in total

1.  Sequence variability of bovine leukemia virus env gene and its relevance to the structure and antigenicity of the glycoproteins.

Authors:  R Z Mamoun; M Morisson; N Rebeyrotte; B Busetta; D Couez; R Kettmann; M Hospital; B Guillemain
Journal:  J Virol       Date:  1990-09       Impact factor: 5.103

2.  Purification by Strep-Tactin affinity chromatography of a delete envelope gp51 protein of Bovine Leukaemia virus expressed in Sf21 insect cells.

Authors:  Antonio De Giuseppe; Katia Forti; Francesco Feliziani; Giulio Severi; Monica Cagiola
Journal:  Protein J       Date:  2010-04       Impact factor: 2.371

3.  Polyclonal bovine sera but not virus-neutralizing monoclonal antibodies block bovine leukemia virus (BLV) gp51 binding to recombinant BLV receptor BLVRcp1.

Authors:  O Orlik; J Ban; J Hlavaty; C Altaner; R Kettmann; D Portetelle; G A Splitter
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

4.  Expression of the bovine leukemia virus envelope glycoprotein (gp51) by recombinant baculovirus and its use in an enzyme-linked immunosorbent assay.

Authors:  Antonio De Giuseppe; Francesco Feliziani; Domenico Rutili; Gian Mario De Mia
Journal:  Clin Diagn Lab Immunol       Date:  2004-01

Review 5.  Preventive and therapeutic strategies for bovine leukemia virus: lessons for HTLV.

Authors:  Sabrina M Rodríguez; Arnaud Florins; Nicolas Gillet; Alix de Brogniez; María Teresa Sánchez-Alcaraz; Mathieu Boxus; Fanny Boulanger; Gerónimo Gutiérrez; Karina Trono; Irene Alvarez; Lucas Vagnoni; Luc Willems
Journal:  Viruses       Date:  2011-07-19       Impact factor: 5.048

6.  Phylogenetic Analysis of South African Bovine Leukaemia Virus (BLV) Isolates.

Authors:  Akiko Suzuki; Rosamund Chapman; Nicola Douglass; Olivia Carulei; Johan van Rensburg; Anna-Lise Williamson
Journal:  Viruses       Date:  2020-08-17       Impact factor: 5.048

7.  Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach.

Authors:  Leandro Buffoni; Laura Garza-Cuartero; Raúl Pérez-Caballero; Rafael Zafra; F Javier Martínez-Moreno; Verónica Molina-Hernández; José Pérez; Álvaro Martínez-Moreno; Grace Mulcahy
Journal:  Parasit Vectors       Date:  2020-07-31       Impact factor: 3.876
  7 in total

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