Literature DB >> 6205095

The effect of epitope density and antibody affinity on the ELISA as analysed by monoclonal antibodies.

A M Lew.   

Abstract

The antibody titre and the optical density values in an ELISA are influenced by the epitope density of the antigen and the affinity of the antibody tested. This has major implications in the interpretation of ELISA results.

Mesh：

Substances：

Year:  1984        PMID： 6205095     DOI： 10.1016/0022-1759(84)90445-9

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  16 in total

Review 1.  Immunochemistry at interfaces.

Authors:  H Nygren; M Stenberg
Journal:  Immunology       Date:  1989-03       Impact factor: 7.397

2.  Antibodies of different human IgG subclasses show distinct patterns of affinity maturation after immunization with keyhole limpet haemocyanin.

Authors:  M E Devey; K M Bleasdale-Barr; P Bird; P L Amlot
Journal:  Immunology       Date:  1990-06       Impact factor: 7.397

3.  Antibody responses to recombinant and plasma derived hepatitis B vaccines.

Authors:  S E Brown; C Stanley; C R Howard; A J Zuckerman; M W Steward
Journal:  Br Med J (Clin Res Ed)       Date:  1986-01-18

4.  Distinctive development of IgG4 subclass antibodies in the primary and secondary responses to keyhole limpet haemocyanin in man.

Authors:  P Bird; J E Calvert; P L Amlot
Journal:  Immunology       Date:  1990-03       Impact factor: 7.397

5.  Determination of IgE antibodies to the benzylpenicilloyl determinant: a comparison of the sensitivity and specificity of three radio allergo sorbent test methods.

Authors:  J J Garcia; M Blanca; F Moreno; J M Vega; C Mayorga; J Fernandez; C Juarez; A Romano; E de Ramon
Journal:  J Clin Lab Anal       Date:  1997       Impact factor: 2.352

6.  Ability of enzyme-linked immunosorbent assays to detect early immunoglobulin G antibodies to Toxoplasma gondii.

Authors:  C Verhofstede; L Sabbe; L Van Renterghem
Journal:  Eur J Clin Microbiol       Date:  1987-04       Impact factor: 3.267

7.  Differences in affinity of anti-CD4 monoclonal antibodies predict their effects on syncytium induction by human immunodeficiency virus.

Authors:  D Wilks; L Walker; J O'Brien; J Habeshaw; A Dalgleish
Journal:  Immunology       Date:  1990-09       Impact factor: 7.397

8.  Definition of Brucella A and M epitopes by monoclonal typing reagents and synthetic oligosaccharides.

Authors:  D R Bundle; J W Cherwonogrodzky; M A Gidney; P J Meikle; M B Perry; T Peters
Journal:  Infect Immun       Date:  1989-09       Impact factor: 3.441

9.  Selection of recombinant, library-derived antibody fragments against p24 for human immunodeficiency virus type 1 diagnostics.

Authors:  H J de Haard; B Kazemier; M J Koolen; L J Nijholt; R H Meloen; B van Gemen; H R Hoogenboom; J W Arends
Journal:  Clin Diagn Lab Immunol       Date:  1998-09

10.  The IgG4 subclass is associated with a low affinity antibody response to tetanus toxoid in man.

Authors:  M E Devey; K M Bleasdale; M A French; G Harrison
Journal:  Immunology       Date:  1985-07       Impact factor: 7.397
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