Literature DB >> 6204735

Elevated concentrations of substance P and 5-HT in plasma in patients with carcinoid tumors.

P C Emson, R F Gilbert, H Martensson, A Nobin.   

Abstract

Ten patients with metastatic carcinoid tumors in the liver showed elevated 5-hydroxytryptamine and substance P levels in plasma samples taken from hepatic or peripheral veins. Chromatographic characterization of the substance P-immunoreactivity showed that by gel permeation and high pressure liquid chromatography the substance P-immunoreactivity was indistinguishable from synthetic undecapeptide substance P. The results suggest that substance P, in addition to the 5-hydroxyinoles, may serve as a circulatory marker for some forms of carcinoid tumors.

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Year:  1984        PMID： 6204735     DOI： 10.1002/1097-0142(1984)54:4<715::aid-cncr2820540420>3.0.co;2-6

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


  11 in total

1.  Two cases of gastric carcinoids: diagnostic and therapeutic aspects.

Authors:  H Ahlman; A Dahlström; L Enerbäck; G Granérus; O Nilsson; S Persson; L E Tisell
Journal:  World J Surg       Date:  1988-06       Impact factor: 3.352

2.  Bronchial carcinoids: an analysis of 91 cases.

Authors:  H Mårtensson; G Böttcher; G Hambraeus; F Sundler; H Willen; A Nobin
Journal:  World J Surg       Date:  1987-06       Impact factor: 3.352

3.  Nuclear DNA patterns and survival in metastasizing ileal carcinoids.

Authors:  A P Nobin; K Erhardt; G Auer; S Falkmer; H Mårtensson
Journal:  World J Surg       Date:  1987-06       Impact factor: 3.352

4.  Effect of a long-acting somatostatin analogue (octreotide) on circulating tachykinins and the pentagastrin-induced carcinoid flush.

Authors:  H J Balks; J M Conlon; W Creutzfeldt; F Stöckmann
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

5.  Capillary permeability induced by intravenous neurokinins. Receptor characterization and mechanism of action.

Authors:  L Jacques; R Couture; G Drapeau; D Regoli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-08       Impact factor: 3.000

6.  A novel tachykinin NK2 receptor antagonist prevents motility-stimulating effects of neurokinin A in small intestine.

Authors:  M Lördal; G Navalesi; E Theodorsson; C A Maggi; P M Hellström
Journal:  Br J Pharmacol       Date:  2001-09       Impact factor: 8.739

7.  Spatial differentiation of the intestinal epithelium: analysis of enteroendocrine cells containing immunoreactive serotonin, secretin, and substance P in normal and transgenic mice.

Authors:  K A Roth; J I Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

8.  Effects of serotonin on rat ileocolonic transit and fluid transfer in vivo: possible mechanisms of action.

Authors:  L Oosterbosch; M von der Ohe; M A Valdovinos; L J Kost; S F Phillips; M Camilleri
Journal:  Gut       Date:  1993-06       Impact factor: 23.059

9.  Medium-term effects of a new 5HT3 antagonist, alosetron, in patients with carcinoid diarrhoea.

Authors:  S B Saslow; J S Scolapio; M Camilleri; L A Forstrom; G M Thomforde; D D Burton; J Rubin; H C Pitot; A R Zinsmeister
Journal:  Gut       Date:  1998-05       Impact factor: 23.059

10.  Carcinoid syndrome: comparison of pretreatment regimes in the same patient.

Authors:  N L Padfield
Journal:  Ann R Coll Surg Engl       Date:  1987-01       Impact factor: 1.891
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