Literature DB >> 620412

Enhancement of X-ray transformation by 12-O-tetradecanoyl-phorbol-13-acetate in a cloned line of C3H mouse embryo cells.

A R Kennedy, S Mondal, C Heidelberger, J B Little.   

Abstract

A phorbol ester promoting agent, 12-O-tetradecanoyl-phorbol-13-acetate, enhances X-ray transformation in vitro in a two-stage fashion similar to that shown previously for ultraviolet radiation and chemical carcinogens. In studies with a mouse embryo-derived cell line (C3H/1OT 1/2 clone 8), there were clear interactive effects between X-radiation and 12-O-tetradecanoylphorbol-13-acetate. These were particularly marked when a minimally transforming X-ray dose (50 or 100 rads) was followed by 12-O-tetradecanoylphorbol-13-acetate treatment beginning either immediately after the radiation exposure or 48 to 96 hr later.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 620412

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  12 in total

1.  The effect of tumor promoters and antagonists on in vitro directional migration of 10T1/2 mouse embryo cells.

Authors:  H Verschueren
Journal:  Cell Biol Toxicol       Date:  1985-06       Impact factor: 6.691

2.  Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.

Authors:  R Zimmerman; P Cerutti
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

3.  On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.

Authors:  A Varshavsky
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

4.  Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells.

Authors:  A R Kennedy; M Fox; G Murphy; J B Little
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

5.  Effect of tumor promoters, protease inhibitors, and repair processes on x-ray-induced sister chromatid exchanges in mouse cells.

Authors:  H Nagasawa; J B Little
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

6.  Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis.

Authors:  A R Kinsella; M Radman
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

7.  Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cells.

Authors:  T Hiwasa; S Fujimura; S Sakiyama
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

8.  Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion.

Authors:  J Lotem; L Sachs
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

9.  Modulation of adenovirus transformation by thyroid hormone.

Authors:  P B Fisher; D L Guernsey; I B Weinstein; I S Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

10.  Can prenatal X-irradiation in mice act as an initiator stimulus in a modified 2-stage Berenblum/Mottram experiment with postnatal promotion with phorbol ester TPA?

Authors:  W Schmahl; H Kriegel; E Senft
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.