Literature DB >> 6203522

Modulation of renal ATPase activities by cyclic AMP.

E M Giesen, J L Imbs, M Grima, M Schmidt, J Schwartz.   

Abstract

A possible link between cellular cyclic AMP content and Na+K+ATPase activity was investigated in homogenates of rat kidney. Enzyme kinetics of Mg2+ and Na+K+ATPase were run in the presence of cyclic AMP, dibutyryl cAMP and compounds expected to elevate cyclic AMP levels such as forskolin, a potent adenylate cyclase activator, IBMX, an inhibitor of phosphodiesterases, and the beta-agonist isoproterenol. Medullary Na+K+ATPase is strongly inhibited by cyclic AMP whereas cortical Na+K+ATPase was stimulated in the same conditions. The correlation between ATPase activity and cellular cyclic AMP content supports the concept of a possible regulation of the enzyme by cyclic AMP.

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Year:  1984        PMID： 6203522     DOI： 10.1016/0006-291x(84)91300-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

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2.  Action of compounds with effective in vivo mineralocorticoid activity on ion transport in leucocytes.

Authors:  D N Baron; R J Green
Journal:  Br J Clin Pharmacol       Date:  1986-01       Impact factor: 4.335

3.  Cyclic AMP enhances acetylcholine (ACh)-induced ion fluxes and catecholamine release by inhibiting Na+, K(+)-ATPase and participates in the responses to ACh in cultured bovine adrenal medullary chromaffin cells.

Authors:  K Morita; N Minami; T Suemitsu; T Miyasako; T Dohi
Journal:  J Neural Transm Gen Sect       Date:  1995

4.  Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells.

Authors:  J P Middleton; J R Raymond; A R Whorton; V W Dennis
Journal:  J Clin Invest       Date:  1990-12       Impact factor: 14.808

5.  Cyclic AMP-induced depolarization measured by bis-oxonol fluorescence in bovine adrenal medullary chromaffin cells.

Authors:  N Minami; K Morita; T Suemitsu; T Miyasako; T Dohi
Journal:  J Neural Transm Gen Sect       Date:  1994

6.  Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells.

Authors:  M L Carranza; M Rousselot; A V Chibalin; A M Bertorello; H Favre; E Féraille
Journal:  J Physiol       Date:  1998-08-15       Impact factor: 5.182

7.  Effect of cilostazol on the neuropathies of streptozotocin-induced diabetic rats.

Authors:  K S Suh; S J Oh; J T Woo; S W Kim; I M Yang; J W Kim; Y S Kim; Y K Choi; I K Park
Journal:  Korean J Intern Med       Date:  1999-07       Impact factor: 2.884
  7 in total

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