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Literature DB >> 6203370

Influence of GABA on anaphylactic histamine release in vitro.

L Zilletti, S Luzzi, S Franchi-Micheli, M Rizzotti, E Rosi, S Spagnesi.

Abstract

In this preliminary report an unreported inhibitory action of GABA on anaphylactic reaction has been described. In a functional model (Schultz-Dale reaction) GABA has been demonstrated to inhibit the antigen-evoked contraction. This effect depends on a modulation of anaphylactic histamine release. The phenomenon is dose-dependent and requires a period of time to develop. Since GABAergic neurons are present in the preparation, it is possible to speculate that GABA receptors are involved in this inhibitory action. However, pharmacological analysis of the phenomenon has to be carried out, especially in view of the latency of GABA to develop its effect.

Entities: Chemical

Mesh：

Substances：
gamma-Aminobutyric Acid

Year: 1984 PMID： 6203370 DOI： 10.1007/bf01973853

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

7 in total

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Journal: Ergeb Physiol Date: 1974

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Authors: N G Bowery; D A Brown
Journal: Br J Pharmacol Date: 1974-02 Impact factor: 8.739

3. The influences of andrenotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro.

Authors: A Giotti; A Guidotti; P F Mannaioni; L Zilletti
Journal: J Physiol Date: 1966-06 Impact factor: 5.182

4. The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips.

Authors: W D Paton; M A Zar
Journal: J Physiol Date: 1968-01 Impact factor: 5.182

5. GABAA and GABAB receptor-mediated effects in guinea-pig ileum.

Authors: A Giotti; S Luzzi; S Spagnesi; L Zilletti
Journal: Br J Pharmacol Date: 1983-03 Impact factor: 8.739

6. Bicuculline-insensitive GABA receptors on peripheral autonomic nerve terminals.

Authors: N G Bowery; A Doble; D R Hill; A L Hudson; J S Shaw; M J Turnbull; R Warrington
Journal: Eur J Pharmacol Date: 1981-04-24 Impact factor: 4.432

7. GABA may be a neurotransmitter in the vertebrate peripheral nervous system.

Authors: K R Jessen; R Mirsky; M E Dennison; G Burnstock
Journal: Nature Date: 1979-09-06 Impact factor: 49.962

7 in total

3 in total