Literature DB >> 6203347

Neuronally mediated non-cholinergic contraction of guinea-pig bronchial smooth muscle is inhibited by a substance P antagonist.

S Leander, N Grundström, R G Andersson, R Håkanson.   

Abstract

The isolated main bronchi of the guinea-pig respond to electrical field stimulation with a twitch followed by a slow contraction. Atropine blocked the slow contraction. The substance P antagonist, (D-Pro2, D- Trp7 ,9)-SP, greatly reduced the atropine-resistant contraction. The results suggest the involvement of substance P in non-cholinergic neurotransmission in the guinea-pig airways.

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Year:  1984        PMID： 6203347     DOI： 10.1007/bf01973819

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

Review 1.  Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena.

Authors:  C Y Kao
Journal:  Pharmacol Rev       Date:  1966-06       Impact factor: 25.468

2.  Substance P antagonists release histamine from peritoneal mast cells.

Authors:  R Håkanson; S Leander; R G Andersson; J Hörig
Journal:  Acta Physiol Scand       Date:  1983-02

3.  Peptide-containing nerve fibres in the airways: distribution and functional implications.

Authors:  R Håkanson; F Sundler; E Moghimzadeh; S Leander
Journal:  Eur J Respir Dis Suppl       Date:  1983

4.  Regulatory peptides in the mammalian respiratory tract.

Authors:  M A Ghatei; M N Sheppard; D J O'Shaughnessy; T E Adrian; G P McGregor; J M Polak; S R Bloom
Journal:  Endocrinology       Date:  1982-10       Impact factor: 4.736

5.  Bronchial smooth muscle contraction induced by stimulation of capsaicin-sensitive sensory neurons.

Authors:  J M Lundberg; A Saria
Journal:  Acta Physiol Scand       Date:  1982-12

6.  A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation.

Authors:  S Leander; R Håkanson; S Rosell; K Folkers; F Sundler; K Tornqvist
Journal:  Nature       Date:  1981-12-03       Impact factor: 49.962

7.  Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall.

Authors:  R Uddman; J Alumets; O Densert; R Håkanson; F Sundler
Journal:  Acta Otolaryngol       Date:  1978 Nov-Dec       Impact factor: 1.494

8.  Pharmacological characterization of the autonomous innervation of the guinea pig tracheobronchial smooth muscle.

Authors:  N Grundström; R G Andersson; J E Wikberg
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1981-08

9.  The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP.

Authors:  R Håkanson; J Hörig; S Leander
Journal:  Br J Pharmacol       Date:  1982-12       Impact factor: 8.739
  9 in total
  1 in total

1.  Suppression by neuropeptide Y of capsaicin-sensitive sensory nerve-mediated contraction in guinea-pig airways.

Authors:  L Grundemar; N Grundström; I G Johansson; R G Andersson; R Håkanson
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739
  1 in total

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