Literature DB >> 6202556

Phorbol ester induces intracellular translocation of phospholipid/Ca2+-dependent protein kinase and stimulates amylase secretion in isolated pancreatic acini.

M W Wooten, R W Wrenn.   

Abstract

Treatment of intact rat pancreatic acini with phorbol ester (12-O-tetradecanoyl-phorbol-13-acetate, TPA) resulted in a time- and concentration-dependent translocation of phospholipid/Ca2+-dependent protein kinase (PL/Ca-PK) from the soluble fraction. Redistribution of PL/Ca-PK was concurrent with stimulation of amylase secretion by TPA-treated acini. Polymyxin B, a potent and selective inhibitor of PL/Ca-PK completely inhibited TPA-induced amylase secretion. These findings are consistent with a role for PL/Ca-PK in the regulation of pancreatic exocrine secretion.

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Year:  1984        PMID： 6202556     DOI： 10.1016/0014-5793(84)80484-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  15 in total

1.  Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis.

Authors:  R E Powers; A K Saluja; M J Houlihan; M L Steer
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

2.  Muscarinic, alpha 1-adrenergic and peptidergic agonists stimulate phosphoinositide hydrolysis and regulate mucin secretion in rat submandibular gland cells.

Authors:  N Fleming; P T Bilan; E Sliwinski-Lis; V Carvalho
Journal:  Pflugers Arch       Date:  1987-08       Impact factor: 3.657

3.  Effects of a phorbol ester and diacylglycerols on secretion of mucin and arginine esterase by rat submandibular gland cells.

Authors:  N Fleming; P T Bilan; E Sliwinski-Lis
Journal:  Pflugers Arch       Date:  1986-01       Impact factor: 3.657

4.  Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin.

Authors:  A E Nel; M W Wooten; G E Landreth; P J Goldschmidt-Clermont; H C Stevenson; P J Miller; R M Galbraith
Journal:  Biochem J       Date:  1986-01-01       Impact factor: 3.857

5.  Effects of stimulation of muscarinic and of beta-catecholamine receptors on the intracellular distribution of protein kinase C in guinea pig exocrine glands.

Authors:  E Machado-de Domenech; H D Söling
Journal:  Biochem J       Date:  1987-03-15       Impact factor: 3.857

6.  Polymyxin B, a selective inhibitor of protein kinase C, diminishes the release of noradrenaline and the enhancement of release caused by phorbol 12,13-butyrate.

Authors:  C Allgaier; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-10       Impact factor: 3.000

7.  The influence of activation or inhibition of protein kinase C on the release of radioactivity from rat isolated atria labelled with [3H]-noradrenaline.

Authors:  E J Ishac; A De Luca
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

8.  Pancreatic amylase secretion and cytoplasmic free calcium. Effects of ionomycin, phorbol dibutyrate and diacylglycerols alone and in combination.

Authors:  J E Merritt; R P Rubin
Journal:  Biochem J       Date:  1985-08-15       Impact factor: 3.857

9.  Effects of a phorbol ester and clomiphene on protein phosphorylation and insulin secretion in rat pancreatic islets.

Authors:  S J Hughes; S J Ashcroft
Journal:  Biochem J       Date:  1988-02-01       Impact factor: 3.857

10.  Characterization of protein kinase C and its role in catecholamine secretion from bovine adrenal-medullary cells.

Authors:  K W Brocklehurst; K Morita; H B Pollard
Journal:  Biochem J       Date:  1985-05-15       Impact factor: 3.857
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