Literature DB >> 6202551

Synergistic effect of A23187 and a phorbol ester on amylase secretion from rabbit pancreatic acini.

J J de Pont, A M Fleuren-Jakobs.   

Abstract

The combination of the ionophore A23187 and the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulates amylase secretion from rabbit pancreatic acini up to a level equal to, or slightly higher than when carbachol is used as stimulant. Each of the two compounds alone gives only a minor stimulation. This synergistic effect of A23187 and TPA supports a role of protein kinase C in pancreatic enzyme secretion.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6202551     DOI： 10.1016/0014-5793(84)81369-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  21 in total

1.  Impaired pancreatic exocrine function in rats with carbon tetrachloride-induced liver cirrhosis.

Authors:  T Ogasawara; T Inagaki; T Yamada; H Ohara; T Nakazawa; M Itoh
Journal:  Int J Pancreatol       Date:  1999-10

2.  Effects of phorbol ester on cholecystokinin octapeptide-evoked exocrine pancreatic secretion in the rat.

Authors:  L P Francis; P J Camello; J Singh; G M Salido; J A Madrid
Journal:  J Physiol       Date:  1990-12       Impact factor: 5.182

3.  Regulation of protein phosphorylation in pancreatic acini. Distinct effects of Ca2+ ionophore A23187 and 12-O-tetradecanoylphorbol 13-acetate.

Authors:  D B Burnham; P Munowitz; S R Hootman; J A Williams
Journal:  Biochem J       Date:  1986-04-01       Impact factor: 3.857

4.  Receptor-evoked Ca2+ mobilization in pancreatic acinar cells: evidence for a regulatory role of protein kinase C by a mechanism involving the transition of high-affinity receptors to a low-affinity state.

Authors:  P H Willems; H J Van Hoof; M G Van Mackelenbergh; J G Hoenderop; S E Van Emst-De Vries; J J De Pont
Journal:  Pflugers Arch       Date:  1993-07       Impact factor: 3.657

Review 5.  The role of phosphoinositides in signal transduction.

Authors:  M C Sekar; L E Hokin
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

6.  Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis.

Authors:  R E Powers; A K Saluja; M J Houlihan; M L Steer
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

7.  Effects of a phorbol ester and diacylglycerols on secretion of mucin and arginine esterase by rat submandibular gland cells.

Authors:  N Fleming; P T Bilan; E Sliwinski-Lis
Journal:  Pflugers Arch       Date:  1986-01       Impact factor: 3.657

8.  Selective regulation of trypsin gene expression by calcium and by glucose starvation in a rat exocrine pancreas cell line.

Authors:  C Stratowa; W J Rutter
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

9.  Cholecystokinin-stimulated enzyme secretion from dispersed rabbit pancreatic acinar cells: phosphorylation-dependent changes in potency and efficacy.

Authors:  P H Willems; S E Van Emst-de Vries; J J De Pont
Journal:  Pflugers Arch       Date:  1995-09       Impact factor: 3.657

10.  The influence of activation or inhibition of protein kinase C on the release of radioactivity from rat isolated atria labelled with [3H]-noradrenaline.

Authors:  E J Ishac; A De Luca
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.