Literature DB >> 6202295

Mechanism of enhanced RNA synthesis in acute-phase rat liver and its relationship to chromatin structure.

L Schiaffonati, L Bardella, G Cairo, V Giancotti, A Bernelli-Zazzera.   

Abstract

Nuclei isolated from the liver of rats undergoing an acute inflammatory reaction induced by turpentine treatment show increased RNA synthesis. This increase is essentially determined by a faster polyribonucleotide-elongation rate while the number of transcribing polymerase molecules is unchanged. The sensitivity of chromatin to micrococcal-nuclease digestion and the composition of chromosomal proteins are not affected by the acute-phase process. Therefore the increased RNA synthesis by liver nuclei from acutely inflamed rats does not seem to correlate with major changes in chromatin structure.

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Year:  1984        PMID： 6202295      PMCID： PMC1153461          DOI： 10.1042/bj2190165

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  28 in total

1.  Changes in nucleolar proteins and their phosphorylation patterns during liver regeneration.

Authors:  N R Ballal; Y J Kang; M O Olson; H Busch
Journal:  J Biol Chem       Date:  1975-08-10       Impact factor: 5.157

2.  The mechanism by which heparin stimulates transcription in isolated rat liver nuclei. Polyribonucleotide elongation rates and the number of transcribing RNA polymerase molecules present.

Authors:  B E Coupar; C J Chesterton
Journal:  Eur J Biochem       Date:  1977-10-03

3.  An octamer of histones in chromatin and free in solution.

Authors:  J O Thomas; R D Kornberg
Journal:  Proc Natl Acad Sci U S A       Date:  1975-07       Impact factor: 11.205

4.  Mechanism of stimulation of chromatin transcription by putrescine: effects on rate of elongation and number of initiation sites utilized.

Authors:  D A Pierce; N Fausto
Journal:  Biochemistry       Date:  1978-01-10       Impact factor: 3.162

5.  A short lived polypeptide component of one of two discrete functional pools of hepatic nuclear alpha-amanitin resistant RNA polymerases.

Authors:  A Lampert; P Feigelson
Journal:  Biochem Biophys Res Commun       Date:  1974-06-18       Impact factor: 3.575

6.  Pre-ribosomal RNA synthesis in isolated rat-liver nucleoli.

Authors:  I Grummt; R Lindigkeit
Journal:  Eur J Biochem       Date:  1973-07-02

7.  Quantification of hepatic transcribing RNA polymerase molecules, polyribonucleotide elongation rates and messenger RNA complexity in fed and fasted rats.

Authors:  B E Coupar; J A Davies; C J Chesterton
Journal:  Eur J Biochem       Date:  1978-03-15

8.  A modification of the acetic acid-urea system for use in microslab polyacrylamide gel electrophoresis.

Authors:  S Spiker
Journal:  Anal Biochem       Date:  1980-11-01       Impact factor: 3.365

9.  Chromatin fractionation procedure that yields nucleosomes containing near-stoichiometric amounts of high mobility group nonhistone chromosomal proteins.

Authors:  J B Jackson; J M Pollock; R L Rill
Journal:  Biochemistry       Date:  1979-08-21       Impact factor: 3.162

10.  Control of the acute phase response. Demonstration of C-reactive protein synthesis and secretion by hepatocytes during acute inflammation in the rabbit.

Authors:  I Kushner; G Feldmann
Journal:  J Exp Med       Date:  1978-08-01       Impact factor: 14.307
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  2 in total

1.  Effect of cytokinins on ribosomal RNA gene expression in excised cotyledons of Cucurbita pepo L.

Authors:  E D Ananiev; L K Karagyozov; E N Karanov
Journal:  Planta       Date:  1987-03       Impact factor: 4.116

2.  Inflammation-associated events in liver nuclei during acute-phase reaction.

Authors:  R Piccoletti; M G Aletti; A Bernelli-Zazzera
Journal:  Inflammation       Date:  1986-06       Impact factor: 4.092
  2 in total

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