| Literature DB >> 620226 |
A B Anderson, E Sklovsky, L Sayers, P A Steele, A C Turnbull.
Abstract
Mean serum concentrations of oestradiol-17beta, oestrone, and oestrone sulphate in postmenopausal women were the same when measured up to six hours after treatment with either piperazine oestrone sulphate 1.5 mg or oestradiol valerate 2 mg. Maximum concentrations of oestradiol were less than those of oestrone, but oestrone sulphate reached concentrations about 30 times higher than those of oestrone. The rapid conversion of oestradiol valerate to oestrone and oestrone sulphate does not support the suggestion that in menopausal women oestradiol is less likely to be associated with a risk of endometrial carcinoma than oestrone sulphate, since the two preparations appear to become identical after ingestion.Entities:
Keywords: Biology; Comparative Studies; Endocrine System; Endometrial Cancer; Estradiol--analysis; Estrogens--administraction and dosage; Estrogens--analysis; Estrogens--therapeutic use; Estrone--analysis; Hematological Effects; Hemic System; Hormones; Menopause; Physiology; Reproduction; Research Methodology; Studies; Women
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Year: 1978 PMID： 620226 PMCID： PMC1602815 DOI： 10.1136/bmj.1.6106.140
Source DB: PubMed Journal: Br Med J ISSN： 0007-1447