Literature DB >> 6202151

Effects of peptides on gastric emptying.

A W Mangel, A Koegel.   

Abstract

The effects of peptides on gastric emptying of a liquid meal were studied in rats. Gastric emptying was found to be delayed following intraperitoneal injection of the octapeptide of cholecystokinin (CCK-8). Vasoactive intestinal peptide did not effect emptying, while substance P and neurotensin caused a moderate acceleration in gastric emptying. After oral administration of a solution containing the amino acids tryptophan and phenylalanine, but not glycine, a statistically significant inhibition of gastric emptying was observed. Our results suggest an involvement of CCK in the regulation of gastric emptying.

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Year:  1984        PMID： 6202151     DOI： 10.1152/ajpgi.1984.246.4.G342

Source DB:  PubMed          Journal:  Am J Physiol        ISSN： 0002-9513


  8 in total

1.  Effect of substance P on rat gastrointestinal transit.

Authors:  P Silkoff; F Karmeli; E Goldin; A Ewenson; C Gilon; M Chorev; R Laufer; Z Selinger; D Rachmilewitz
Journal:  Dig Dis Sci       Date:  1988-01       Impact factor: 3.199

2.  Central effects of pituitary adenylate cyclase activating polypeptide (PACAP) on gastric motility and emptying in rats.

Authors:  M Ozawa; M Aono; M Moriga
Journal:  Dig Dis Sci       Date:  1999-04       Impact factor: 3.199

3.  Vasoactive intestinal peptide. An inhibitor of feline gastric smooth muscle in vitro.

Authors:  A Merlo; S Cohen
Journal:  Dig Dis Sci       Date:  1989-09       Impact factor: 3.199

4.  Gastric neuropeptides and gastric motor abnormality in streptozotocin-induced diabetic rats: observation for four weeks after streptozotocin.

Authors:  Y Miyamoto; M Yoneda; A Morikawa; H Itoh; I Makino
Journal:  Dig Dis Sci       Date:  2001-08       Impact factor: 3.199

5.  Stimulation and inhibition of gastrointestinal propulsion induced by substance P and substance K in the rat.

Authors:  P Holzer
Journal:  Br J Pharmacol       Date:  1985-09       Impact factor: 8.739

6.  Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats.

Authors:  Chiu-Lung Wu; Chen-Road Hung; Full-Young Chang; K-Y Francis Pau; Paulus S Wang
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-02-26       Impact factor: 3.000

7.  Physiological role of cholecystokinin on gastric emptying and acid output in dogs.

Authors:  H O Jin; K Y Lee; T M Chang; W Y Chey; A Dubois
Journal:  Dig Dis Sci       Date:  1994-11       Impact factor: 3.199

8.  A tachykinin antagonist inhibits gastric emptying and gastrointestinal transit in the rat.

Authors:  P Holzer; U Holzer-Petsche; S Leander
Journal:  Br J Pharmacol       Date:  1986-11       Impact factor: 8.739
  8 in total

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