Literature DB >> 62018

Anti-idiotype sera raised against surface immunoglobulin of human neoplastic lymphocytes.

D W Hough, R P Eady, T J Hamblin, F K Stevenson, G T Stevenson.   

Abstract

The idiotypic determinants of surface immunoglobulins on B-cell lymphomas and lymphocytic leukemias represent tumor-specific antigens, individually unique for each tumor. As such they have both diagnostic and therapeutic potential, particularly for those neoplasms with no serum monoclonal immunoglobulin arising from synthesis of the protein for export. We describe the raising in animals of anti-idiotype sera directed against two examples of a nonexporting neoplasm, human chronic lymphocytic leukemia. The procedure involves exposing the cells to papain so as to remove the Fab fragments (containing the idiotypic determinants) from the surface immunoglobulin, recovering the Fab on cellulose immunosorbent particles, and immunizing animals with the immunosorbent-Fab complex.

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Year:  1976        PMID： 62018      PMCID： PMC2190432          DOI： 10.1084/jem.144.4.960

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  29 in total

1.  Immunisation with antigen coupled to an immunosorbent.

Authors:  G T Stevenson
Journal:  Nature       Date:  1974-02-15       Impact factor: 49.962

2.  Spectrum of ovine immunoglobulins.

Authors:  I C Pan; A M Kaplan; R L Morter; M J Freeman
Journal:  Proc Soc Exp Biol Med       Date:  1968-12

3.  Syngeneic immune serum specifically inhibits the motility of tumour cells.

Authors:  G A Currie; G C Sime
Journal:  Nat New Biol       Date:  1973-02-28

4.  Lymphocytes forming red cell rosettes in the cold in patients with chronic cold agglutinin disease.

Authors:  T Feizi; P Wernet; H G Kunkel; S D Douglas
Journal:  Blood       Date:  1973-11       Impact factor: 22.113

5.  Identification of two populations of immunoglobulin-bearing lymphocytes in man.

Authors:  P I Lobo; F B Westervelt; D A Horwitz
Journal:  J Immunol       Date:  1975-01       Impact factor: 5.422

6.  Myeloma proteins as tumor-specific transplantation antigens.

Authors:  R G Lynch; R J Graff; S Sirisinha; E S Simms; H N Eisen
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

7.  Mutant lines of guinea pig L2C leukemia. I. Deletion of Ia alloantigens is associated with a loss in immunogenicity of tumor-associated transplantation antigens.

Authors:  G Forni; E M Shevach; I Green
Journal:  J Exp Med       Date:  1976-05-01       Impact factor: 14.307

8.  Idiotypic uniformity of cell surface immunoglobulin in chronic lymphocytic leukeima. Evidence for monoclonal proliferation.

Authors:  K R Schroer; D E Briles; J A Van Boxel; J M Davie
Journal:  J Exp Med       Date:  1974-11-01       Impact factor: 14.307

9.  Active suppression of immunoglobulin allotype synthesis. 3. Identification of T cells as responsible for suppression by cells from spleen, thymus, lymph node, and bone marrow.

Authors:  L A Herzenberg; E L Chan; M M Ravitch; R J Riblet; L A Herzenberg
Journal:  J Exp Med       Date:  1973-06-01       Impact factor: 14.307

10.  Idiotypic determinants of immunoglobulin M detected on the surface of human lymphocytes by cytotoxicity assays.

Authors:  P Wernet; T Feizi; H G Kunkel
Journal:  J Exp Med       Date:  1972-09-01       Impact factor: 14.307
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  18 in total

1.  How well can an idiotope peptide mimic replace its parent idiotype in a synthetic peptide vaccine?

Authors:  James S Cavenaugh; Hsu-kun Wang; Jiang Sha; Corey Hansen; Kongnara Papangkorn; Richard S Smith; James N Herron
Journal:  Pharm Res       Date:  2004-08       Impact factor: 4.200

2.  Cell-bound immunoglobulin on peripheral blood mononuclear cells of patients with myeloma.

Authors:  M A King; J V Wells
Journal:  Clin Exp Immunol       Date:  1981-09       Impact factor: 4.330

3.  Antigenic modulation of lymphocytic surface immunoglobulin yielding resistance to complement-mediated lysis. I. Characterization with syngeneic and xenogeneic complements.

Authors:  J Gordon; D S Robinson; G T Stevenson
Journal:  Immunology       Date:  1981-01       Impact factor: 7.397

4.  Immune guided missiles.

Authors:  T J Hamblin
Journal:  Br Med J (Clin Res Ed)       Date:  1982-08-14

5.  Further studies of immunoglobulin synthesis by guinea pig leukaemic lymphocytes.

Authors:  D W Hough; J C Chapple; F K Stevenson; G T Stevenson
Journal:  Immunology       Date:  1978-05       Impact factor: 7.397

6.  Rescue of immunoglobulin secretion from human neoplastic lymphoid cells by somatic cell hybridization.

Authors:  R Levy; J Dilley
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

Review 7.  Three major uncertainties in the antibody therapy of cancer.

Authors:  George T Stevenson
Journal:  Haematologica       Date:  2014-10       Impact factor: 9.941

8.  The assessment of anti-idiopathic antibodies as effective immunoregulatory probes in vivo.

Authors:  J C Olson; C R Wagner; G A Leslie
Journal:  Clin Exp Immunol       Date:  1982-05       Impact factor: 4.330

9.  Characterization of a human monoclonal autoantibody directed to cardiolipin/beta 2 glycoprotein I produced by chronic lymphocytic leukaemia B cells.

Authors:  X Mariette; Y Levy; M L Dubreuil; L Intrator; F Danon; J C Brouet
Journal:  Clin Exp Immunol       Date:  1993-11       Impact factor: 4.330

10.  Lymphoblastoid cell lines from patients with chronic lymphocytic leukemia: identification of tumor origin by idiotypic analysis.

Authors:  J N Hurley; S M Fu; H G Kunkel; G McKenna; M D Scharff
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205
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