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Literature DB >> 6201749

Interleukin-3 supports growth of mouse pre-B-cell clones in vitro.

R Palacios, G Henson, M Steinmetz, J P McKearn.

Abstract

Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered by the inability to maintain homogeneous populations of precursor cells in vitro. We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of interleukin-3 dependent pre-B-cell clones that can be induced to mature into antibody secreting cells in vitro.

Entities: CellLine Gene Species

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Year: 1984 PMID： 6201749 DOI： 10.1038/309126a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

41 in total

1. B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment.

Authors: D Weaver; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1987-03 Impact factor: 11.205

2. Biochemical and physiochemical characteristics of a pre-B cell stimulating factor produced by the plasmacytoma cell line LICR LON HMY2.

Authors: A Trudgett; A C Fay; J M Thompson; T A McNeill
Journal: Clin Exp Immunol Date: 1985-03 Impact factor: 4.330

3. IL-3 promotes the development of experimental autoimmune encephalitis.

Authors: Kerstin Renner; Sonja Hellerbrand; Fabian Hermann; Christine Riedhammer; Yvonne Talke; Gabriela Schiechl; Manuel Rodriguez Gomez; Simone Kutzi; Dagmar Halbritter; Nicole Goebel; Hilke Brühl; Robert Weissert; Matthias Mack
Journal: JCI Insight Date: 2016-10-06

4. Presence of a very small population of Thy-1+, L3T4+ cells producing large amounts of IL-3 in young athymic nude mice.

Authors: M Kimoto; S de Kossodo; V Kindler; M Detraz; P Vassalli; S Izui
Journal: Immunology Date: 1989-12 Impact factor: 7.397

Review 5. Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection.

Authors: R R Bartlett; M Dimitrijevic; T Mattar; T Zielinski; T Germann; E Rüde; G H Thoenes; C C Küchle; H U Schorlemmer; E Bremer
Journal: Agents Actions Date: 1991-01

6. Concanavalin A-stimulated rat spleen cells produce a soluble factor that supports growth of the mouse IL-3-dependent cell line Ea3.123, but not three other IL-3-dependent lines.

Authors: J A Carron; S Marshall-Clarke
Journal: Immunology Date: 1986-08 Impact factor: 7.397

Interleukin-3 supports growth of mouse pre-B-cell clones in vitro.

1. B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment.

2. Biochemical and physiochemical characteristics of a pre-B cell stimulating factor produced by the plasmacytoma cell line LICR LON HMY2.

3. IL-3 promotes the development of experimental autoimmune encephalitis.

4. Presence of a very small population of Thy-1+, L3T4+ cells producing large amounts of IL-3 in young athymic nude mice.

Review 5. Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection.

6. Concanavalin A-stimulated rat spleen cells produce a soluble factor that supports growth of the mouse IL-3-dependent cell line Ea3.123, but not three other IL-3-dependent lines.

7. Stimulation of hematopoiesis in vivo by recombinant bacterial murine interleukin 3.

8. An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance.

9. Negative regulation of early B lymphopoiesis by interleukin 3 and interleukin 1 alpha.

10. Transcriptional activation of vesicular monoamine transporter 2 in the pre-B cell line Ea3.123.