| Literature DB >> 6201685 |
R L Momparler, J Bouchard, N Onetto, G E Rivard.
Abstract
The effect of 5-aza-2'-deoxycytidine (5-AZA-dCyd) on methylation of DNA in blood leukemic cells from patients with lymphoid and myeloid leukemia was investigated. After treatment with continuous infusion of 5-AZA-dCyd (1.0 mg/kg/h) the blood leukemic cells were isolated and incubated in vitro with [6-3H]deoxycytidine and the incorporation of radioactivity into 5-methylcytosine and cytosine of DNA determined. 5-AZA-dCyd produced greater than 70% inhibition of DNA methylation in the leukemic cells. The antileukemic action of 5-AZA-dCyd may be related to the inhibition of DNA methylation.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6201685 DOI： 10.1016/0145-2126(84)90141-3
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156