Literature DB >> 6200940

Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics.

T Papayannopoulou, A Torrealba de Ron, R Veith, G Knitter, G Stamatoyannopoulos.   

Abstract

Arabinosylcytosine, a compound that inhibits DNA synthesis in rapidly dividing cells, stimulates fetal hemoglobin in adult baboons and produces significant perturbations in the pools of erythroid progenitors. It appears that changes in the kinetics of erythroid cell differentiation rather than direct action on the gamma genes underlie stimulation of fetal hemoglobin in the adult animals in vivo. These results also suggest that chemotherapeutic agents selected for their low carcinogenic or mutagenic potential could be used for therapeutic induction of fetal hemoglobin in patients with sickle cell anemia.

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Year:  1984        PMID： 6200940     DOI： 10.1126/science.6200940

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  27 in total

1.  Induction of human gamma globin gene expression by histone deacetylase inhibitors.

Authors:  Hua Cao; George Stamatoyannopoulos; Manfred Jung
Journal:  Blood       Date:  2003-08-14       Impact factor: 22.113

2.  The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease.

Authors:  Tohru Ikuta; Adekunle D Adekile; Diana R Gutsaeva; James B Parkerson; Shobha D Yerigenahally; Betsy Clair; Abdullah Kutlar; Nadine Odo; C Alvin Head
Journal:  Blood Cells Mol Dis       Date:  2011-09-25       Impact factor: 3.039

Review 3.  Control of globin gene expression during development and erythroid differentiation.

Authors:  George Stamatoyannopoulos
Journal:  Exp Hematol       Date:  2005-03       Impact factor: 3.084

4.  Old genes for new: a possible approach to the management of some genetic diseases?

Authors:  C Bunch
Journal:  J R Soc Med       Date:  1985-07       Impact factor: 5.344

Review 5.  Pharmacological modification of hemoglobin F expression in sickle cell anemia: an update on hydroxyurea studies.

Authors:  S Charache
Journal:  Experientia       Date:  1993-02-15

6.  The switch from fetal to adult hemoglobin.

Authors:  Vijay G Sankaran; Stuart H Orkin
Journal:  Cold Spring Harb Perspect Med       Date:  2013-01-01       Impact factor: 6.915

7.  5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin.

Authors:  R K Humphries; G Dover; N S Young; J G Moore; S Charache; T Ley; A W Nienhuis
Journal:  J Clin Invest       Date:  1985-02       Impact factor: 14.808

8.  MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.

Authors:  Vijay G Sankaran; Tobias F Menne; Danilo Šćepanović; Jo-Anne Vergilio; Peng Ji; Jinkuk Kim; Prathapan Thiru; Stuart H Orkin; Eric S Lander; Harvey F Lodish
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-04       Impact factor: 11.205

9.  Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis.

Authors:  N L Letvin; D C Linch; G P Beardsley; K W McIntyre; B A Miller; D G Nathan
Journal:  J Clin Invest       Date:  1985-06       Impact factor: 14.808

10.  Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemia.

Authors:  Aisha L Walker; Shirley Steward; Thad A Howard; Nicole Mortier; Matthew Smeltzer; Yong-Dong Wang; Russell E Ware
Journal:  Blood       Date:  2011-09-14       Impact factor: 22.113
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