Literature DB >> 6199667

Purine metabolism in Leishmania donovani amastigotes and promastigotes.

D L Looker, R L Berens, J J Marr.   

Abstract

Purine metabolism in Leishmania donovani amastigotes was found to be similar to that of promastigotes with the exception of adenosine metabolism. Adenosine kinase activity in amastigotes is approximately 50-fold greater than in promastigotes. Amastigotes deaminate adenosine to inosine through adenosine deaminase, an enzyme not present in promastigotes. Inosine is cleaved to hypoxanthine and phosphoribosylated by hypoxanthine-guanine phosphoribosyltransferase. Promastigotes cleave adenosine to adenine and deaminate adenine to hypoxanthine via adenase, an enzyme not present in amastigotes. Hypoxanthine is phosphoribosylated by hypoxanthine-guanine phosphoribosyltransferase.

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Year:  1983        PMID： 6199667     DOI： 10.1016/0166-6851(83)90053-1

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  22 in total

1.  Molecular cloning and expression of adenosine kinase from Leishmania donovani: identification of unconventional P-loop motif.

Authors:  K M Sinha; M Ghosh; I Das; A K Datta
Journal:  Biochem J       Date:  1999-05-01       Impact factor: 3.857

Review 2.  Purine salvage in Leishmania: complex or simple by design?

Authors:  Jan M Boitz; Buddy Ullman; Armando Jardim; Nicola S Carter
Journal:  Trends Parasitol       Date:  2012-06-20

3.  Oxidation of hemoglobin and redistribution of band 3 promote erythrophagocytosis in visceral leishmaniasis.

Authors:  Sudipa Saha Roy; Kaustav Dutta Chowdhury; Gargi Sen; Tuli Biswas
Journal:  Mol Cell Biochem       Date:  2008-09-06       Impact factor: 3.396

Review 4.  Biochemistry of the Leishmania species.

Authors:  R H Glew; A K Saha; S Das; A T Remaley
Journal:  Microbiol Rev       Date:  1988-12

5.  Amplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases.

Authors:  Jan M Boitz; Buddy Ullman
Journal:  J Biol Chem       Date:  2010-04-02       Impact factor: 5.157

6.  Homology-model-guided site-specific mutagenesis reveals the mechanisms of substrate binding and product-regulation of adenosine kinase from Leishmania donovani.

Authors:  Rupak Datta; Ishita Das; Banibrata Sen; Anutosh Chakraborty; Subrata Adak; Chhabinath Mandal; Alok K Datta
Journal:  Biochem J       Date:  2006-02-15       Impact factor: 3.857

7.  Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.

Authors:  Wai-Lok Yau; Thierry Blisnick; Jean-François Taly; Manuela Helmer-Citterich; Cordelia Schiene-Fischer; Olivier Leclercq; Jing Li; Dirk Schmidt-Arras; Miguel A Morales; Cedric Notredame; Daniel Romo; Philippe Bastin; Gerald F Späth
Journal:  PLoS Negl Trop Dis       Date:  2010-06-29

8.  GMP reductase and genetic uncoupling of adenylate and guanylate metabolism in Leishmania donovani parasites.

Authors:  Jan M Boitz; Armando Jardim; Buddy Ullman
Journal:  Mol Biochem Parasitol       Date:  2016-06-22       Impact factor: 1.759

9.  Adenylosuccinate synthetase and adenylosuccinate lyase deficiencies trigger growth and infectivity deficits in Leishmania donovani.

Authors:  Jan M Boitz; Rona Strasser; Phillip A Yates; Armando Jardim; Buddy Ullman
Journal:  J Biol Chem       Date:  2013-02-12       Impact factor: 5.157

10.  Two conformationally vicinal thiols at the active site of Leishmania donovani adenosine kinase.

Authors:  T K Bagui; M Ghosh; A K Datta
Journal:  Biochem J       Date:  1996-06-01       Impact factor: 3.857
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