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Literature DB >> 619952

Anticoagulant activity of the enantiomers of acenocoumarol.

T Meinertz, W Kasper, C Kahl, E Jähnchen.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 1978 PMID： 619952 PMCID： PMC1429246 DOI： 10.1111/j.1365-2125.1978.tb01622.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

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11 in total

1. Studies on the optical enantiomorphs of warfarin in man.

Authors: R A O'Reilly
Journal: Clin Pharmacol Ther Date: 1974-08 Impact factor: 6.875

2. Relationship between the kinetics of the anticoagulant effects of racemic warfarin and its individual enantiomers in man.

Authors: G Levy; R A O'Reilly; L B Wingard
Journal: Res Commun Chem Pathol Pharmacol Date: 1974-02

3. The plasma half-lives of the enantiomers of warfarin in warfarin-resistant and warfarin-susceptible rats.

Authors: D S Hewick
Journal: J Pharm Pharmacol Date: 1972-08 Impact factor: 3.765

4. Pharmacokinetics of the warfarin enantiomers in rats.

Authors: A Yacobi; G Levy
Journal: J Pharmacokinet Biopharm Date: 1974-06

5. The plasma half lives and the pharmacological effect of the enantiomers of warfarin in rats.

Authors: A Breckenridge; M L Orme
Journal: Life Sci II Date: 1972-04-08

6. Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man.

Authors: D S Hewick; J McEwen
Journal: J Pharm Pharmacol Date: 1973-06 Impact factor: 3.765

7. Stereoselective drug distribution and anticoagulant potency of the enantiomers of phenprocoumon in rats.

Authors: W Schmidt; E Jähnchen
Journal: J Pharm Pharmacol Date: 1977-05 Impact factor: 3.765

8. The enantiomers of phenprocoumon: pharmacodynamic and pharmacokinetic studies.

Authors: E Jähnchen; T Meinertz; H J Gilfrich; U Groth; A Martini
Journal: Clin Pharmacol Ther Date: 1976-09 Impact factor: 6.875

9. Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone.

Authors: R J Lewis; W F Trager; K K Chan; A Breckenridge; M Orme; M Roland; W Schary
Journal: J Clin Invest Date: 1974-06 Impact factor: 14.808

10. Biotransformation and pharmacokinetics of acenocoumarol (Sintrom) in man.

Authors: W Dieterle; J W Faigle; C Montigel; M Sulc; W Theobald
Journal: Eur J Clin Pharmacol Date: 1977 Impact factor: 2.953

12 in total

Review 1. Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.

Authors: Mike Ufer
Journal: Clin Pharmacokinet Date: 2005 Impact factor: 6.447

2. Acenocoumarol sensitivity and pharmacokinetic characterization of CYP2C9 5/8,8/11,9/11 and VKORC1*2 in black African healthy Beninese subjects.

Authors: Aurel Constant Allabi; Yves Horsmans; Jean-Claude Alvarez; André Bigot; Roger K Verbeeck; Umit Yasar; Jean-Luc Gala
Journal: Eur J Drug Metab Pharmacokinet Date: 2011-08-03 Impact factor: 2.441

Anticoagulant activity of the enantiomers of acenocoumarol.

1. Studies on the optical enantiomorphs of warfarin in man.

2. Relationship between the kinetics of the anticoagulant effects of racemic warfarin and its individual enantiomers in man.

3. The plasma half-lives of the enantiomers of warfarin in warfarin-resistant and warfarin-susceptible rats.

4. Pharmacokinetics of the warfarin enantiomers in rats.

5. The plasma half lives and the pharmacological effect of the enantiomers of warfarin in rats.

6. Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man.

7. Stereoselective drug distribution and anticoagulant potency of the enantiomers of phenprocoumon in rats.

8. The enantiomers of phenprocoumon: pharmacodynamic and pharmacokinetic studies.

9. Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone.

10. Biotransformation and pharmacokinetics of acenocoumarol (Sintrom) in man.

Review 1. Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.

2. Acenocoumarol sensitivity and pharmacokinetic characterization of CYP2C9 5/8,8/11,9/11 and VKORC1*2 in black African healthy Beninese subjects.

Review 3. Importance of drug enantiomers in clinical pharmacology.

Review 4. New oral anticoagulants: comparative pharmacology with vitamin K antagonists.

5. Active metabolites of acenocoumarol: do they contribute to the therapeutic effect?

6. Pharmacokinetics of the enantiomers of acenocoumarol in man.

Review 7. Clinical pharmacokinetics of oral anticoagulants.

Review 8. Clinically important drug interactions with anticoagulants. An update.

9. Vitamin K 2,3-epoxide reductase: the basis for stereoselectivity of 4-hydroxycoumarin anticoagulant activity.

10. Lack of effect of cimetidine on pharmacodynamics and kinetics of single oral doses of R- and S-acenocoumarol.