Literature DB >> 6199292

Allospecific suppression without requirement for participation of Ly 2+ cells.

V Holán, N A Mitchison.   

Abstract

Haplotype-specific suppressor T cells (Ts) were induced by incubation of mouse spleen/lymph node cells with allogeneic heat-treated cells. These Ts have an Ly 1+2- phenotype, and can be activated in cultures depleted of Ly 2+ cells by treatment with anti-Ly 2 antibodies and complement. In addition, these Ts inhibit alloantigen-induced proliferation of Ly 1+2- cells without the participation of Ly 2+ cells. These results show that allospecific suppressor T cells can be activated and can act without participation of Ly 2+, thus demonstrating that Ly 1+2- cells can directly suppress proliferation of other Ly 1+2- cells.

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Year:  1984        PMID： 6199292      PMCID： PMC1454473     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  20 in total

1.  Selective activation of human suppressor cells by a nonproliferative stimulus.

Authors:  P M Sondel; M W Jacobson; F H Bach
Journal:  Eur J Immunol       Date:  1977-01       Impact factor: 5.532

2.  Discrimination of suppressor T cells of humoral and cell-mediated immunity by anti-Ly and anti-Ia sera.

Authors:  I A Ramshaw; I F McKenzie; P A Bretscher; C R Parish
Journal:  Cell Immunol       Date:  1977-06-15       Impact factor: 4.868

Review 3.  Immunological circuits: cellular composition.

Authors:  H Cantor; R K Gershon
Journal:  Fed Proc       Date:  1979-06

4.  Production and characterization of cytotoxic Thy-1 antibody-secreting hybrid cell lines. Detection of T cell subsets.

Authors:  P Lake; E A Clark; M Khorshidi; G H Sunshine
Journal:  Eur J Immunol       Date:  1979-11       Impact factor: 5.532

Review 5.  Fine specificity analysis with monoclonal antibodies of antigens controlled by the major histocompatibility complex and by the Qa/TL region in mice.

Authors:  H Lemke; G J Hämmerling; U Hämmerling
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

Review 6.  Immunoregulatory T-cell pathways.

Authors:  D R Green; P M Flood; R K Gershon
Journal:  Annu Rev Immunol       Date:  1983       Impact factor: 28.527

7.  A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression.

Authors:  B Benacerraf; R N Germain
Journal:  Scand J Immunol       Date:  1981       Impact factor: 3.487

8.  Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.

Authors:  H Cantor; J Hugenberger; L McVay-Boudreau; D D Eardley; J Kemp; F W Shen; R K Gershon
Journal:  J Exp Med       Date:  1978-10-01       Impact factor: 14.307

9.  Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.

Authors:  M A Vadas; J F Miller; I F McKenzie; S E Chism; F W Shen; E A Boyse; J R Gamble; A M Whitelaw
Journal:  J Exp Med       Date:  1976-07-01       Impact factor: 14.307

10.  Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.

Authors:  D D Eardley; J Hugenberger; L McVay-Boudreau; F W Shen; R K Gershon; H Cantor
Journal:  J Exp Med       Date:  1978-04-01       Impact factor: 14.307
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  2 in total

1.  Establishment and characterization of a permanent T-cell line producing an antigen non-specific suppressor factor.

Authors:  V Holán; M Lipoldová; M Takác; J Cerná; A Vancatová; D Cechová; L Veselský; M Hasek
Journal:  Immunology       Date:  1985-10       Impact factor: 7.397

2.  Cyclophosphamide (Cy)-facilitated adoptive immunotherapy of a Cy-resistant tumour. Evidence that Cy permits the expression of adoptive T-cell mediated immunity by removing suppressor T cells rather than by reducing tumour burden.

Authors:  M Awwad; R J North
Journal:  Immunology       Date:  1988-09       Impact factor: 7.397
  2 in total

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