| Literature DB >> 6199090 |
S R Zukin, K T Brady, B L Slifer, R L Balster.
Abstract
The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at mu opiate and sigma opiate/phencyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands.Entities:
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Year: 1984 PMID： 6199090 DOI： 10.1016/0006-8993(84)91326-x
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252