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Literature DB >> 6198458

Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy.

Abstract

Kynurenine, tryptophan and 5-hydroxyindoleacetic acid were measured in human lumbar and cisternal cerebrospinal fluid (CSF) taken during pneumoencephalography. The results do not support the hypothesis that any substantial part of the CSF kynurenine is of central origin. However, the results suggest that CSF kynurenine is reduced in some epileptic subjects and this seems to be due to the disease rather than anticonvulsants. This finding is of interest in view of the reported convulsant effect of kynurenine in experimental animals.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6198458 DOI： 10.1007/bf01252805

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

26 in total

1. CSF amino acids and plasma--CSF amino acid ratios in adults.

Authors: T L Perry; S Hansen; J Kennedy
Journal: J Neurochem Date: 1975-03 Impact factor: 5.372

2. Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: effect of cirrhosis of liver and probenecid administration.

Authors: S N Young; S Lal; T L Sourkes; F Feldmuller; A Aronoff; J B Martin
Journal: J Neurol Neurosurg Psychiatry Date: 1975-04 Impact factor: 10.154

8. Kynurenine: penetration to the brain, effect on brain tryptophan and 5-hydroxytryptamine metabolism and binding to plasma albumin [proceedings].

Authors: M H Joseph; B V Kadam
Journal: Br J Pharmacol Date: 1979-07 Impact factor: 8.739

Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy.

1. CSF amino acids and plasma--CSF amino acid ratios in adults.

2. Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: effect of cirrhosis of liver and probenecid administration.

3. Cerebral tryptophan-2,3-dioxygenase (pyrrolase) and its induction in rat brain.

4. The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway.

Review 5. Monoamine metabolites in lumbar CSF: the question of their origin in relation to clinical studies.

6. The effect of tryptophan metabolites on brain 5-hydroxytryptamine metabolism.

7. Interaction of kynurenine and its metabolites with tryptamine, serotonin and its precursors and oxotremorine.

8. Kynurenine: penetration to the brain, effect on brain tryptophan and 5-hydroxytryptamine metabolism and binding to plasma albumin [proceedings].

9. Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS.

10. Liquid chromatographic-fluorometric system for the determination of indoles in physiological samples.

1. Kynurenine pathway metabolites in humans: disease and healthy States.

2. Effect of quinolinic acid on wakefulness and sleep in the rabbit.