Literature DB >> 6197320

Galanin - a novel biologically active peptide from porcine intestine.

K Tatemoto, A Rökaeus, H Jörnvall, T J McDonald, V Mutt.   

Abstract

The isolation of a novel biologically active peptide, designated galanin, is described. The peptide was discovered by the detection of its C-terminal amide structure in porcine intestinal extract using a chemical method. It was found that galanin consists of 29 amino acids and the complete amino acid sequence is: Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His -Arg-Ser -Phe-His-Asp-Lys-Tyr-Gly-Leu-Ala-NH2. Galanin was found to contract smooth muscle preparations from the rat and to cause a mild and sustained hyperglycemia in dog.

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Year:  1983        PMID： 6197320     DOI： 10.1016/0014-5793(83)80033-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  196 in total

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3.  CSF galanin and cognition after shunt surgery in normal pressure hydrocephalus.

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4.  Temporal-Spatial Profiling of Pedunculopontine Galanin-Cholinergic Neurons in the Lactacystin Rat Model of Parkinson's Disease.

Authors:  Joanna L Elson; Rafael Kochaj; Richard Reynolds; Ilse S Pienaar
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5.  A short estrogen-responsive N-terminal galanin homologue found in rat brain and gut with antiserum raised against rat galanin(1-16).

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Journal:  Neurochem Res       Date:  2006-04-04       Impact factor: 3.996

6.  Purification of a galanin receptor from pig brain.

Authors:  Y Chen; A Fournier; A Couvineau; M Laburthe; B Amiranoff
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

7.  Galanin-like immunoreactivity in extrinsic and intrinsic nerves to the gut of the Atlantic cod, Gadus morhua, and the effect of galanin on the smooth muscle of the gut.

Authors:  P Karila; A C Jönsson; J Jensen; S Holmgren
Journal:  Cell Tissue Res       Date:  1993-03       Impact factor: 5.249

8.  Galanin-like immunoreactivity in the chicken brain.

Authors:  R Józsa; B Mess
Journal:  Cell Tissue Res       Date:  1993-08       Impact factor: 5.249

9.  Modulation of galanin and neuromedin U-like immunoreactivity in rat corticotropes after alteration of endocrine status.

Authors:  V Cimini; S Van Noorden; C M Timson; J M Polak
Journal:  Cell Tissue Res       Date:  1993-04       Impact factor: 5.249

10.  Characterization of a high-affinity galanin receptor in the rat anterior pituitary: absence of biological effect and reduced membrane binding of the antagonist M15 differentiate it from the brain/gut receptor.

Authors:  D Wynick; D M Smith; M Ghatei; K Akinsanya; R Bhogal; P Purkiss; P Byfield; N Yanaihara; S R Bloom
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205
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