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Literature DB >> 6197122

Substance P inhibits the M-current in bullfrog sympathetic neurones.

Abstract

Substance P (SP, 2.5-10 microM) was applied by rapid bath perfusion to bullfrog lumbar sympathetic neurones in vitro, voltage-clamped through a single micro-electrode. In unclamped cells, SP produced a depolarization accompanied by an increase in apparent input resistance. Under voltage-clamp a voltage-dependent inward current was induced by SP, during which the time-dependent relaxations induced by square voltage commands were inhibited. It is concluded that SP inhibits the M-current (IM), a species of voltage-dependent K+-current, and that IM-inhibition was the primary cause of the inward current and membrane depolarization in the cells tested.

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Year: 1983 PMID： 6197122 PMCID： PMC2044878 DOI： 10.1111/j.1476-5381.1983.tb11004.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

14 in total

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Authors: Y N Jan; L Y Jan; S W Kuffler
Journal: Proc Natl Acad Sci U S A Date: 1979-03 Impact factor: 11.205

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Authors: L Y Jan; Y N Jan
Journal: J Physiol Date: 1982-06 Impact factor: 5.182

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Authors: T J Sejnowski
Journal: Fed Proc Date: 1982-11

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Authors: D A Brown; A Constanti; P R Adams
Journal: Fed Proc Date: 1981-09

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Authors: Y N Jan; L Y Jan; S W Kuffler
Journal: Proc Natl Acad Sci U S A Date: 1980-08 Impact factor: 11.205

6. Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone.

Authors: D A Brown; P R Adams
Journal: Nature Date: 1980-02-14 Impact factor: 49.962

7. Two chemically and immunologically distinct forms of luteinizing hormone-releasing hormone are differentially expressed in frog neural tissues.

Authors: L E Eiden; E Loumaye; N Sherwood; R L Eskay
Journal: Peptides Date: 1982 May-Jun Impact factor: 3.750

8. Synaptic inhibition of the M-current: slow excitatory post-synaptic potential mechanism in bullfrog sympathetic neurones.

Authors: P R Adams; D A Brown
Journal: J Physiol Date: 1982-11 Impact factor: 5.182

9. M-currents and other potassium currents in bullfrog sympathetic neurones.

Authors: P R Adams; D A Brown; A Constanti
Journal: J Physiol Date: 1982-09 Impact factor: 5.182

10. Slow synaptic responses in autonomic ganglia and the pursuit of a peptidergic transmitter.

Authors: S W Kuffler
Journal: J Exp Biol Date: 1980-12 Impact factor: 3.312

25 in total

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2. Modulation of inwardly rectifying channels by substance P in cholinergic neurones from rat brain in culture.

Authors: K Yamaguchi; Y Nakajima; S Nakajima; P R Stanfield
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3. Time course of receptor-channel coupling in frog sympathetic neurons.

Authors: S W Jones
Journal: Biophys J Date: 1991-08 Impact factor: 4.033

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Authors: J J Dreifuss; M Raggenbass
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6. Protein kinase C is not necessary for peptide-induced suppression of M current or for desensitization of the peptide receptors.

Authors: M M Bosma; B Hille
Journal: Proc Natl Acad Sci U S A Date: 1989-04 Impact factor: 11.205

7. Multiple actions of substance P that regulate the functional properties of acetylcholine receptors of clonal rat PC12 cells.

Authors: N D Boyd; S E Leeman
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8. Tachykinins as mediators of slow EPSPs in guinea-pig gall-bladder ganglia: involvement of neurokinin-3 receptors.

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9. Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers.

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