Literature DB >> 6196724

Complete structure of the porcine pro-opiomelanocortin mRNA derived from the nucleotide sequence of cloned cDNA.

G Boileau, C Barbeau, L Jeannotte, M Chrétien, J Drouin.   

Abstract

Polyadenylated RNA isolated from porcine pituitary neurointermediate lobes was used to construct a cDNA library. The library was screened with a rat genomic DNA fragment specific for pro-opiomelanocortin sequences. Two positive clones, pJA-19 and pJA-20, containing respectively 850 bp and 550 bp were characterized. Sequence analysis of the cDNA inserts revealed the complete structure of the porcine pro-opiomelanocortin mRNA. This mRNA would include 129 5'-untranslated nucleotides, 801 nucleotides coding for the 267 amino acids precursor and 162 3'-untranslated nucleotides. Comparison with pro-opiomelanocortin mRNA sequences from other species shows regions of high homology not only in the coding sequences but also in the 5'untranslated region where the first 50 nucleotides are over 80% purines.

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Year:  1983        PMID： 6196724      PMCID： PMC326560          DOI： 10.1093/nar/11.22.8063

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  33 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

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Authors:  J L Roberts; E Herbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

3.  Comparative study on analgesic effect of Met5-enkephalin and related lipotropin fragments.

Authors:  L Graf; J I Szekely; A Z Ronai; Z Dunai-Kovacs; S Bajusz
Journal:  Nature       Date:  1976-09-16       Impact factor: 49.962

4.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.

Authors:  P W Rigby; M Dieckmann; C Rhodes; P Berg
Journal:  J Mol Biol       Date:  1977-06-15       Impact factor: 5.469

5.  Screening lambdagt recombinant clones by hybridization to single plaques in situ.

Authors:  W D Benton; R W Davis
Journal:  Science       Date:  1977-04-08       Impact factor: 47.728

6.  Revised amino-acid sequences for porcine and human adrenocorticotrophic hormone.

Authors:  B Riniker; P Sieber; W Rittel; H Zuber
Journal:  Nat New Biol       Date:  1972-01-26

7.  Rapid inactivation of ovalbumin messenger ribonucleic acid after acute withdrawal of estrogen.

Authors:  R D Palmiter; N H Carey
Journal:  Proc Natl Acad Sci U S A       Date:  1974-06       Impact factor: 11.205

8.  Rate of ovalbumin messenger ribonucleic acid synthesis in the oviduct of estrogen-primed chicks.

Authors:  R D Palmiter
Journal:  J Biol Chem       Date:  1973-12-10       Impact factor: 5.157

9.  3' non-coding region sequences in eukaryotic messenger RNA.

Authors:  N J Proudfoot; G G Brownlee
Journal:  Nature       Date:  1976-09-16       Impact factor: 49.962

10.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors:  H Aviv; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205
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  11 in total

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Journal:  Trans Am Clin Climatol Assoc       Date:  1991

2.  Secretion of a functional soluble form of neutral endopeptidase-24.11 from a baculovirus-infected insect cell line.

Authors:  F Fossiez; G Lemay; N Labonté; F Parmentier-Lesage; G Boileau; P Crine
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

3.  Nucleotide sequence of a cloned cDNA for proopiomelanocortin precursor of chum salmon, Onchorynchus keta.

Authors:  G I Soma; N Kitahara; T Nishizawa; H Nanami; C Kotake; H Okazaki; T Andoh
Journal:  Nucleic Acids Res       Date:  1984-11-12       Impact factor: 16.971

Review 4.  Compilation of published signal sequences.

Authors:  M E Watson
Journal:  Nucleic Acids Res       Date:  1984-07-11       Impact factor: 16.971

Review 5.  POMC: The Physiological Power of Hormone Processing.

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Journal:  Physiol Rev       Date:  2018-10-01       Impact factor: 37.312

Review 6.  Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration.

Authors:  Koon-Sea Hui
Journal:  Neurochem Res       Date:  2007-05-03       Impact factor: 3.996

7.  Beta-turn secondary structure and melanocortin ligands.

Authors:  Erica M Haslach; Jay W Schaub; Carrie Haskell-Luevano
Journal:  Bioorg Med Chem       Date:  2008-03-04       Impact factor: 3.641

8.  Characterization of proopiomelanocortin transcripts in human nonpituitary tissues.

Authors:  T Lacaze-Masmonteil; Y de Keyzer; J P Luton; A Kahn; X Bertagna
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

9.  Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression.

Authors:  Lydiane Funkelstein; Thomas Toneff; Charles Mosier; Shin-Rong Hwang; Felix Beuschlein; Urs D Lichtenauer; Thomas Reinheckel; Christoph Peters; Vivian Hook
Journal:  J Biol Chem       Date:  2008-10-10       Impact factor: 5.157

10.  Altered proopiomelanocortin gene expression in adrenocorticotropin-producing nonpituitary tumors. Comparative studies with corticotropic adenomas and normal pituitaries.

Authors:  Y de Keyzer; X Bertagna; F Lenne; F Girard; J P Luton; A Kahn
Journal:  J Clin Invest       Date:  1985-11       Impact factor: 14.808
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