Literature DB >> 6196446

In vivo measurement of dopamine and its metabolites by intracerebral dialysis: changes after d-amphetamine.

T Zetterström, T Sharp, C A Marsden, U Ungerstedt.   

Abstract

By using a new technique, intracerebral dialysis, in combination with high performance liquid chromatography and electrochemical detection, it was possible to recover and measure endogenous extracellular dopamine, together with its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) from the striatum and nucleus accumbens of anaesthetized or freely moving rats. In addition, measurements of extracellular 5-hydroxyindoleacetic acid, ascorbic acid, and uric acid were made. Basal extracellular concentrations of dopamine and DOPAC in the striatum were estimated to be 5 X 10(-8) M and 5 X 10(-6) M, respectively. d-Amphetamine (2 mg/kg s.c.) increased dopamine levels in the striatum perfusates by 14-fold, whereas levels of DOPAC and HVA decreased by 77% and 66%, respectively.

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Year:  1983        PMID： 6196446     DOI： 10.1111/j.1471-4159.1983.tb00893.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  79 in total

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4.  Differential post-mortem release of noradrenaline and dopamine: a re-evaluation.

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5.  Benzodiazepine prevention of swim stress-induced sensitization of cortical biogenic amines: an in vivo microdialysis study.

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Review 7.  Do autoreceptors mediate dopamine agonist--induced yawning and suppression of exploration? A critical review.

Authors:  L Ståhle
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

8.  Previous stress increases in vivo biogenic amine response to swim stress.

Authors:  S Jordan; G L Kramer; P K Zukas; F Petty
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9.  Ontogeny of behavioral sensitization in the rat: effects of direct and indirect dopamine agonists.

Authors:  S A McDougall; M A Duke; C A Bolanos; C A Crawford
Journal:  Psychopharmacology (Berl)       Date:  1994-12       Impact factor: 4.530

10.  Characterization of binding sites for [125I]R(+)trans-7-OH-PIPAT in rat brain.

Authors:  M P Kung; S Chumpradit; D Frederick; S Garner; K D Burris; P B Molinoff; H F Kung
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