Literature DB >> 6196423

Effect of minoxidil on cultured keratinocytes.

H P Baden, J Kubilus.   

Abstract

Minoxidil has been shown to stimulate hair growth and these studies were undertaken to determine whether the drug had a direct effect on keratinocytes. Cultures of human epidermal cells were treated with minoxidil and it was found that they survived longer than control cultures. In addition, minoxidil prolonged the time that cells could be passed after reaching confluence. The results suggest that minoxidil slows the senescence of keratinocytes, which is similar to what has been found with epidermal growth factor.

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Year:  1983        PMID： 6196423     DOI： 10.1111/1523-1747.ep12523220

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  6 in total

Review 1.  Topical minoxidil. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in alopecia areata and alopecia androgenetica.

Authors:  S P Clissold; R C Heel
Journal:  Drugs       Date:  1987-02       Impact factor: 9.546

2.  Male pattern baldness and its management: an update.

Authors:  P C Cotterill; W P Unger
Journal:  Can Fam Physician       Date:  1987-11       Impact factor: 3.275

3.  Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1.

Authors:  Tiina A Jokela; Katri M Makkonen; Sanna Oikari; Riikka Kärnä; Elina Koli; Gerald W Hart; Raija H Tammi; Carsten Carlberg; Markku I Tammi
Journal:  J Biol Chem       Date:  2011-07-27       Impact factor: 5.157

4.  Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro.

Authors:  K Katsuoka; H Schell; B Wessel; O P Hornstein
Journal:  Arch Dermatol Res       Date:  1987       Impact factor: 3.017

5.  Isolation and characterization of a spontaneously arising long-lived line of human keratinocytes (NM 1).

Authors:  H P Baden; J Kubilus; J C Kvedar; M L Steinberg; S R Wolman
Journal:  In Vitro Cell Dev Biol       Date:  1987-03

6.  Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells.

Authors:  Erkin Pekmezci; Murat Turkoğlu; Hilal Gökalp; Zekayi Kutlubay
Journal:  Int J Trichology       Date:  2018 May-Jun
  6 in total

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