Literature DB >> 6194742

The idiotypic network: internal images of rabbit immunoglobulin allotopes.

P A Cazenave, J Roland, E Petit-Koskas.   

Abstract

Internal recognition is a primordial concept in the idiotypic network hypothesis proposed by N. Jerne. The analysis of idiotypic recurrence in rabbit antiallotypic antibodies led us to propose the existence of antiidiotypic molecules Ab2 beta carrying idiotopes which are internal images of the original immunizing allotype. Using mouse monoclonal antibodies, we have shown that the internal image of b6 rabbit allotopes is associated with the internal image of kappa 1 isotypic determinants. The influence of interactions within the idiotypic network on the evolution of the immunological repertoire is discussed.

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Year:  1983        PMID： 6194742     DOI： 10.1016/s0769-2625(83)80051-8

Source DB:  PubMed          Journal:  Ann Immunol (Paris)        ISSN： 0300-4910


  3 in total

1.  T-cell activation by anti-idiotypic antibody: evidence for the internal image.

Authors:  A D Rees; K Praputpittaya; A Scoging; N Dobson; J Ivanyi; D Young; J R Lamb
Journal:  Immunology       Date:  1987-03       Impact factor: 7.397

2.  A genomic gene encoding the b5 rabbit immunoglobulin kappa constant region: implications for latent allotype phenomenon.

Authors:  L Emorine; J A Sogn; D Trinh; T J Kindt; E E Max
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

3.  Yeast killer toxin-like candidacidal Ab6 antibodies elicited through the manipulation of the idiotypic cascade.

Authors:  Luciano Polonelli; Concetta Beninati; Giuseppe Teti; Franco Felici; Tecla Ciociola; Laura Giovati; Martina Sperindè; Carla Lo Passo; Ida Pernice; Maria Domina; Milena Arigò; Salvatore Papasergi; Giuseppe Mancuso; Stefania Conti; Walter Magliani
Journal:  PLoS One       Date:  2014-08-27       Impact factor: 3.240
  3 in total

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