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Literature DB >> 6194509

Differential inhibition of cellular RNAs by photosensitized trioxalen.

Abstract

Treatment of mouse cell cultures with 5 X 10(-6)M trioxalen (4,5',8-trimethylpsoralen, or TMP) followed by long wavelength ("near") UV-irradiation (NUV) resulted in immediate cessation of most of the cellular transcriptional activity. The effective inhibitory TMP concentrations for ribosomal RNA were lower than those affecting poly RNA containing RNA. Low molecular RNA species were only partially inhibited. Side effects, commonly caused by other drugs, were not detected. These properties, and the simplicity of their use, make psoralens attractive inhibitors of RNA biosynthesis.

Entities: Chemical Species

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Year: 1983 PMID： 6194509 PMCID： PMC326385 DOI： 10.1093/nar/11.18.6453

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

25 in total

1. Stability of HeLa cell mRNA in actinomycin.

Authors: R H Singer; S Penman
Journal: Nature Date: 1972-11-10 Impact factor: 49.962

2. Effects of actinomycin D, toyocamycin and cycloheximide on the synthesis of low-molecular-weight nuclear RNAs in HeLa cells.

Authors: R Hamelin; C J Larsen; A Tavitian
Journal: Eur J Biochem Date: 1973-06

3. Ribonucleic acid synthesis in animal cells in the presence of actinomycin.

Authors: R Stern; R M Friedman
Journal: Biochemistry Date: 1971-09-28 Impact factor: 3.162

4. Light-induced cross-linking of DNA in the presence of a furocoumarin (psoralen). Studies with phage lambda, Escherichia coli, and mouse leukemia cells.

Authors: R S Cole
Journal: Biochim Biophys Acta Date: 1970-09-17

5. The role of deoxyribonucleic acid in ribonucleic acid synthesis. XIV. A study of the initiation of ribonucleic acid synthesis.

Authors: U Maitra; Y Nakata; J Hurwitz
Journal: J Biol Chem Date: 1967-11-10 Impact factor: 5.157

Differential inhibition of cellular RNAs by photosensitized trioxalen.

1. Stability of HeLa cell mRNA in actinomycin.

2. Effects of actinomycin D, toyocamycin and cycloheximide on the synthesis of low-molecular-weight nuclear RNAs in HeLa cells.

3. Ribonucleic acid synthesis in animal cells in the presence of actinomycin.

4. Light-induced cross-linking of DNA in the presence of a furocoumarin (psoralen). Studies with phage lambda, Escherichia coli, and mouse leukemia cells.

5. The role of deoxyribonucleic acid in ribonucleic acid synthesis. XIV. A study of the initiation of ribonucleic acid synthesis.

6. Unphysiological breakdown of fast-labelled RNA by actinomycin D in primary chick fibroblasts.

7. Studies on the photo-C4-cyclo-addition reactions between skin-photosensitizing furocoumarins and nucleic acids.

8. Kinetics of the in vitro inhibition of transcription by actinomycin.

9. Double-stranded RNA synthesized in animal cells in the presence of actinomycin D.

10. Purification and properties of biologically active messenger RNA for a myeloma light chain.

1. Selective killing of transformed rat cells by minute virus of mice does not require infectious virus production.

2. The effects of covalent additions of a psoralen on transcription by E. coli RNA polymerase.