Arterial changes during treatment with intrahepatic arterial infusion of 5-fluorouracil.

Changes in the liver arteries ranging from minimal irregularities in occlusions and development of aneurysms were investigated in 27 patients who received intra-arterial infusion of 5-FU in the hepatic artery. Variations in the arterial caliber peripheral to the hilum of the liver were noted in 13 of the patients. Further investigation of such arterial changes may be important in controlling the growth of liver metastases.