Literature DB >> 6194289

Vasoactive intestinal polypeptide: a putative transmitter in the canine gastric muscularis mucosa.

F Angel, V L Go, P F Schmalz, J H Szurszewski.   

Abstract

The nature of the inhibitory transmitter in the canine gastric muscularis mucosae was studied in vitro using superfusion techniques. The inhibitory effect of nerve stimulation (10 V, 200 mus, 10 Hz) was not altered by adrenergic, cholinergic or serotonergic antagonists. Adenosine triphosphate had no effect on spontaneous mechanical activity. Nucleotide pyrophosphatase and apamin had no effect on the response to nerve stimulation. Alpha-chymotrypsin abolished the inhibitory effect of nerve stimulation. Radioimmunoassay of the muscle indicated the presence of gastrin/cholecystokinin-substance P- and vasoactive intestinal polypeptide (VIP)-like immunoreactivity. Of the three peptides present, only VIP produced a concentration-dependent relaxation. A substance with VIP-like immunoreactivity was released during nerve-induced relaxation of the muscle, and its release was blocked by tetrodotoxin and calcium-depleted solution. The inhibitory effect of nerve stimulation was abolished by VIP antiserum. These data strongly support the hypothesis that VIP or a closely related peptide is an inhibitory neurotransmitter in the canine gastric muscularis mucosae.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6194289      PMCID： PMC1195355          DOI： 10.1113/jphysiol.1983.sp014830

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  17 in total

1.  On the VIP-ergic innervation of the feline pylorus.

Authors:  R Edin; J M Lundberg; H Ahlman; A Dahlström; J Fahrenkrug; T Hökfelt; J Kewenter
Journal:  Acta Physiol Scand       Date:  1979-10

2.  Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea-pig: immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine beta-hydroxylase.

Authors:  M Schultzberg; T Hökfelt; G Nilsson; L Terenius; J F Rehfeld; M Brown; R Elde; M Goldstein; S Said
Journal:  Neuroscience       Date:  1980       Impact factor: 3.590

3.  Studies of autonomic nerves in the gut-past, present and future.

Authors:  G Burnstock
Journal:  Scand J Gastroenterol Suppl       Date:  1982

Review 4.  Review lecture. Neurotransmitters and trophic factors in the autonomic nervous system.

Authors:  G Burnstock
Journal:  J Physiol       Date:  1981       Impact factor: 5.182

5.  Distribution of enteric nerve cell bodies and axons showing immunoreactivity for vasoactive intestinal polypeptide in the guinea-pig intestine.

Authors:  M Costa; J B Furness; R Buffa; S I Said
Journal:  Neuroscience       Date:  1980       Impact factor: 3.590

6.  Nucleotide pyrophosphatase antagonizes responses to adenosine 5'-triphosphate and non-adrenergic, non-cholinergic inhibitory nerve stimulation in the guinea-pig isolated taenia coli.

Authors:  D G Satchell
Journal:  Br J Pharmacol       Date:  1981-10       Impact factor: 8.739

7.  Release of vasoactive intestinal polypeptide (VIP) by electric stimulation of the vagal nerves.

Authors:  O B Schaffalitzky de Muckadell; J Fahrenkrug; J J Holst
Journal:  Gastroenterology       Date:  1977-02       Impact factor: 22.682

8.  Detection and characterisation of neurotransmitters, particularly peptides, in the gastrointestinal tract.

Authors:  J B Furness; M Costa; R Murphy; A M Beardsley; J R Oliver; I J Llewellyn-Smith; R L Eskay; A A Shulkes; T W Moody; D K Meyer
Journal:  Scand J Gastroenterol Suppl       Date:  1982

9.  Peptide-containing neurones connect the two ganglionated plexuses of the enteric nervous system.

Authors:  K R Jessen; J M Polak; S Van Noorden; S R Bloom; G Burnstock
Journal:  Nature       Date:  1980-01-24       Impact factor: 49.962

10.  Evidence against vasoactive intestinal polypeptide being the non-adrenergic, non-cholinergic inhibitory transmitter released from nerves supplying the smooth muscle of the guinea-pig taenia coli.

Authors:  I Mackenzie; G Burnstock
Journal:  Eur J Pharmacol       Date:  1980-10-17       Impact factor: 4.432
View more
  15 in total

1.  Localization of nitric oxide synthase in canine ileocolonic and pyloric sphincters.

Authors:  S M Ward; C Xue; K M Sanders
Journal:  Cell Tissue Res       Date:  1994-03       Impact factor: 5.249

2.  Different innervation mechanisms between the lesser and greater curvature of guinea pig antrum.

Authors:  T Takahashi; M Kantoh; M Kusunoki; T Yamamura; J Utsunomiya
Journal:  Dig Dis Sci       Date:  1989-02       Impact factor: 3.199

Review 3.  Vasoactive intestinal peptide.

Authors:  S I Said
Journal:  J Endocrinol Invest       Date:  1986-04       Impact factor: 4.256

4.  Innervation of the muscularis mucosae of canine proximal colon.

Authors:  F Angel; V L Go; J H Szurszewski
Journal:  J Physiol       Date:  1984-12       Impact factor: 5.182

5.  Increase in participation of vasoactive intestinal peptide in relaxation of the distal colon of Wistar rats with age.

Authors:  T Takeuchi; T Negoro; M Yamaji; Y Yamazaki; A Fujita; H Nishio; T Takewaki; K Takatsuji; F Hata
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739

6.  Vasoactive intestinal peptide. An inhibitor of feline gastric smooth muscle in vitro.

Authors:  A Merlo; S Cohen
Journal:  Dig Dis Sci       Date:  1989-09       Impact factor: 3.199

7.  Human isolated small intestine: motor responses of the longitudinal muscle to field stimulation and exogenous neuropeptides.

Authors:  C A Maggi; R Patacchini; P Santicioli; S Giuliani; D Turini; G Barbanti; P Beneforti; D Misuri; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-04       Impact factor: 3.000

8.  Light- and electron-microscopic immunochemical analysis of nerve fibre types innervating the taenia of the guinea-pig caecum.

Authors:  J B Furness; S Pompolo; C W Shuttleworth; D E Burleigh
Journal:  Cell Tissue Res       Date:  1992-10       Impact factor: 5.249

9.  Influence of alpha-chymotrypsin and trypsin on the non-adrenergic non-cholinergic relaxation in the rat gastric fundus.

Authors:  F A De Beurme; R A Lefebvre
Journal:  Br J Pharmacol       Date:  1987-05       Impact factor: 8.739

10.  Evidence against vasoactive intestinal polypeptide as the relaxant neurotransmitter in human cavernosal smooth muscle.

Authors:  R S Pickard; P H Powell; M A Zar
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.