Literature DB >> 6193914

Functional maturity of cord blood B lymphocytes: Staphylococcus aureus Cowan 1 induces IgG secretion in the human neonate.

A M Unander, L Hammarström, C I Smith.   

Abstract

Lymphocytes from newborn infants and adults were investigated with the polyclonal B cell activators Staphylococcus aureus Cowan 1, soluble protein A, and pokeweed mitogen (PWM). In cord blood lymphocytes (CBL), protein A and PWM induced only meagre IgM responses, whereas Cowan 1 bacteria induced synthesis of both IgM and IgG in quantities comparable to adult levels. We were also able to establish the neonatal origin of the Ig producing cells. Thus, cord blood lymphocytes seem to be functionally mature enough to produce any Ig class, provided they are given the right stimulus.

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Year:  1983        PMID： 6193914      PMCID： PMC1535640     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  26 in total

1.  Ontogeny of B-lymphocyte differentiation induced by pokeweed mitogen.

Authors:  L Y Wu; A Blanco; M D Cooper; A R Lawton
Journal:  Clin Immunol Immunopathol       Date:  1976-03

2.  Induction of plasma cell differentiation of human fetal lymphocytes: evidence for functional immaturity of T and B cells.

Authors:  A R Hayward; A R Lawton
Journal:  J Immunol       Date:  1977-10       Impact factor: 5.422

3.  A correlative immunologic, microbiologic and clinical approach to the diagnosis of acute and chronic infections in newborn infants.

Authors:  C A Alford; J Schaefer; W J Blankenship; J V Straumfjord; G Cassady
Journal:  N Engl J Med       Date:  1967-08-31       Impact factor: 91.245

4.  Elevated cord macroglobulins in the diagnosis of intrauterine infections.

Authors:  E R Stiehm; A J Ammann; J D Cherry
Journal:  N Engl J Med       Date:  1966-11-03       Impact factor: 91.245

5.  Immunofluorescent studies of the development of pre-B cells, B lymphocytes and immunoglobulin isotype diversity in humans.

Authors:  W E Gathings; A R Lawton; M D Cooper
Journal:  Eur J Immunol       Date:  1977-11       Impact factor: 5.532

6.  Differentiation of cord blood lymphocytes into IgA-producing cells in response to breast milk stimulatory factor.

Authors:  W B Pittard; K Bill
Journal:  Clin Immunol Immunopathol       Date:  1979-08

7.  Protein A-positive staphylococci serve as a selective B cell mitogen for lymphocytes from primary immunodeficiency patients.

Authors:  M C Sirianni; F Pandolfi; F Aiuti; H Wigzell
Journal:  Clin Exp Immunol       Date:  1979-04       Impact factor: 4.330

8.  Studies of human cord blood and adult lymphocyte interactions with in vitro immunoglobulin production.

Authors:  T Morito; A D Bankhurst; R C Williams
Journal:  J Clin Invest       Date:  1979-10       Impact factor: 14.808

9.  Polyclonal antibody secretion in human lymphocytes induced by killed staphylococcal bacteria and by lipopolysaccharide.

Authors:  O Ringdén; B Rynnel-Dagöö; E M Waterfield; E Möller; G Möller
Journal:  Scand J Immunol       Date:  1977       Impact factor: 3.487

10.  The immunological development of the human fetus.

Authors:  R van Furth; H R Schuit; W Hijmans
Journal:  J Exp Med       Date:  1965-12-01       Impact factor: 14.307
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  3 in total

1.  The role of interleukin 2 in the regulation of proliferation and IgM synthesis of human newborn mononuclear cells.

Authors:  J Punnonen
Journal:  Clin Exp Immunol       Date:  1989-03       Impact factor: 4.330

2.  Increased susceptibility of cord blood B lymphocytes to undergo spontaneous apoptosis.

Authors:  A Kessel; D Yehudai; R Peri; E Pavlotzky; E Bamberger; N Tov; E Toubi
Journal:  Clin Exp Immunol       Date:  2006-09       Impact factor: 4.330

3.  Cord blood contains cells secreting antibodies to nervous system components.

Authors:  S Fredrikson; J Sun; B G Xiao; H Link
Journal:  Clin Exp Immunol       Date:  1991-05       Impact factor: 4.330
  3 in total

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