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Literature DB >> 6193440

Labeling of RNA in young and adult rat brain: evidence for different RNA processing.

I Serra, A Cupello, M N Gadaleta, M Viola, P Ragonese, A M Giuffrida.

Abstract

The labeling of RNA in young and adult rat brain has been studied by measuring in vitro (tissue slices incubation) the incorporation of labeled uridine into RNA of total tissue and of the various subcellular fractions purified from cerebral hemispheres of 1- and 10-month-old rats. Gel electrophoretic analysis of the newly synthesized nuclear and microsomal RNA was also accomplished. An active metabolism of RNA in adult animals was found; moreover, distinct differences in ribosomal RNA processing in cerebral hemispheres of 1- and 10-month-old rats, with a more rapid processing in the brain of adult animals, were obtained.

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Year: 1983 PMID： 6193440 DOI： 10.1007/bf00965100

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

22 in total

1. RNA polymerade activity in various classes of nuclei from different regions of rat brain during postnatal development.

Authors: A M Giufrida; D Cox; A P Mathias
Journal: J Neurochem Date: 1975-04 Impact factor: 5.372

2. A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.

Authors: G SCHMIDT; S J THANNHAUSER
Journal: J Biol Chem Date: 1945 Impact factor: 5.157

3. The metabolism of high-molecular-weight ribonucleic acid including polyadenylated species, in the developing rat brain.

Authors: W Berthold; L Lim
Journal: Biochem J Date: 1976-02-15 Impact factor: 3.857

4. Biosynthesis of nucleic acids in different regions of rat brain during postnatal development.

Authors: A M Giuffrida; I Serra; L Fiore; A Vanella; A Cozzolino
Journal: Ital J Biochem Date: 1974 Mar-Apr

5. Differentiation of chick embryo cerebral hemispheres. II. Incorporation of ( 3 H)uridine into 29 S, 18 S, 5 S and 4 S RNA.

Authors: C Judes; M Jacob
Journal: Brain Res Date: 1973-03-15 Impact factor: 3.252

6. Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipids in the tissues of the rat.

Authors: N J Gross; G S Getz; M Rabinowitz
Journal: J Biol Chem Date: 1969-03-25 Impact factor: 5.157

7. Brain poly(A)RNA during aging: stability of yield and sequence complexity in two rat strains.

Authors: P D Colman; B B Kaplan; H H Osterburg; C E Finch
Journal: J Neurochem Date: 1980-02 Impact factor: 5.372

8. Use of a single tissue extract to determine cellular protein and nucleic acid concentrations and rate of amino acid incorporation.

Authors: R W Wannemacher; W L Banks; W H Wunner
Journal: Anal Biochem Date: 1965-05 Impact factor: 3.365

9. Macromolecular synthesis in mitochondria isolated from different regions of developing rat brain.

Authors: M N Gadaleta; A M Giuffrida; M Renis; I Serra; G Del Prete; E Geremia; C Saccone
Journal: Neurochem Res Date: 1979-02 Impact factor: 3.996

10. The metabolism of high-molecular-weight ribonucleic acid in hypothalamic and cortical regions of the developing female rat brain.

Authors: C Hall; L Lim
Journal: Biochem J Date: 1978-11-15 Impact factor: 3.857

5 in total

1. Differential effects of axotomy on immature and mature hamster facial neurons: a tritiated-uridine autoradiographic study.

Authors: K J Jones; A LaVelle
Journal: Metab Brain Dis Date: 1987-12 Impact factor: 3.584