Literature DB >> 6193006

Ocular responses evoked by capsaicin and prostaglandin E2 are inhibited by a substance P antagonist.

G Bynke, R Håkanson, J Hörig.   

Abstract

Injection of capsaicin or prostaglandin E2 into the vitreous chamber of the rabbit eye resulted in miosis and breakdown of the blood-aqueous barrier, manifested in aqueous flare. Pretreatment with the neuronal blocker tetrodotoxin or the substance P antagonist (D-Pro, D-Trp)-SP greatly reduced the ocular responses to capsaicin and prostaglandin E2. The results suggest a role for neuronal substance P in the ocular response to injury.

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Year:  1983        PMID： 6193006     DOI： 10.1007/bf01989769

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  23 in total

1.  AQUEOUS FLOW DETERMINATION IN THE RABBIT BY MEANS OF A MINIMAL EYE TRAUMA.

Authors:  K DYSTER-AAS; C E KRAKAU
Journal:  Invest Ophthalmol       Date:  1964-04

2.  The pathophysiological effects of nitrogen mustard on the rabbit eye. II. The inhibition of the initial hypertensive phase by capsaicin and the apparent role of substance P.

Authors:  C B Camras; L Z Bito
Journal:  Invest Ophthalmol Vis Sci       Date:  1980-04       Impact factor: 4.799

3.  Immunoreactivity for substance P in the Gasserian ganglion, ophthalmic nerve and anterior segment of the rabbit eye.

Authors:  K Tervo; T Tervo; L Eränkö; O Eränkö; A C Cuello
Journal:  Histochem J       Date:  1981-05

4.  Neurogenic responses of the eye to injury. Effect of sensory denervation on the response of the rabbit eye to bradykinin and prostaglandin E1.

Authors:  J M Butler; B Hammond
Journal:  Trans Ophthalmol Soc U K       Date:  1977-09

5.  Substance P in trigeminal nerve endings: occurrence and release.

Authors:  E Brodin; B Gazelius; J M Lundberg; L Olgart
Journal:  Acta Physiol Scand       Date:  1981-04

6.  Substance P: release on trigeminal nerve stimulation, effects in the eye.

Authors:  A Bill; J Stjernschantz; A Mandahl; E Brodin; G Nilsson
Journal:  Acta Physiol Scand       Date:  1979-07

7.  Substance P, vasoactive intestinal polypeptide (VIP) and somatostatin levels in ocular tissue of normal and sensorily denervated rabbit eyes.

Authors:  W G Unger; J M Butler; D F Cole; S R Bloom; G P McGregor
Journal:  Exp Eye Res       Date:  1981-06       Impact factor: 3.467

Review 8.  Prostaglandin and non-prostaglandin mediated breeakdown of the blood-aqueous barrier.

Authors:  K E Eakins
Journal:  Exp Eye Res       Date:  1977       Impact factor: 3.467

9.  Ocular responses to antidromic trigeminal stimulation, intracameral prostaglandin E1 and E2, capsaicin and substance P.

Authors:  A Mandahl; A Bill
Journal:  Acta Physiol Scand       Date:  1981-07

10.  The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP.

Authors:  R Håkanson; J Hörig; S Leander
Journal:  Br J Pharmacol       Date:  1982-12       Impact factor: 8.739
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  4 in total

1.  Sympathectomy enhances the substance P-mediated breakdown of the blood-aqueous barrier in response to infrared irradiation of the rabbit iris.

Authors:  G Bynke; A Bruun; R Håkanson
Journal:  Experientia       Date:  1985-04-15

2.  Substance P antagonists and mucociliary activity in rabbit.

Authors:  S Lindberg; U Mercke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-06       Impact factor: 3.000

3.  Neurogenic inflammation in skin blisters.

Authors:  R D Helme; D M White; P V Andrews
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972

4.  Long-term administration of a substance P antagonist, (D-Pro2, D-Trp7,9)-SP, abolishes the response to ocular trauma.

Authors:  G Bynke; R Håkanson; J Hörig; K Folkers
Journal:  Experientia       Date:  1984-04-15
  4 in total

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