Literature DB >> 6192817

Agents that increase cellular cAMP inhibit production of interleukin-2, but not its activity.

A Novogrodsky, M Patya, A L Rubin, K H Stenzel.   

Abstract

Proliferation of lectin-treated mouse thymocytes induced by the tumor promoter, 12-0-tetradecanoyl-13-acetate, is markedly inhibited by cAMP analogues, prostaglandin E and methylisobutylxanthine. Proliferation induced by interleukin-2 is resistant to inhibition by these compounds. The tumor promoter induces interleukin-2 production in a subpopulation of lectin-treated thymocytes, and production of this lymphokine is inhibited by agents that increase cellular cAMP.

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Year:  1983        PMID： 6192817     DOI： 10.1016/0006-291x(83)91598-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

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Authors:  R H Straub; R Wiest; U G Strauch; P Härle; J Schölmerich
Journal:  Gut       Date:  2006-11       Impact factor: 23.059

3.  cAMP antagonizes interleukin 2-promoted T-cell cycle progression at a discrete point in early G1.

Authors:  K W Johnson; B H Davis; K A Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

4.  T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

Authors:  C H June; J A Ledbetter; M M Gillespie; T Lindsten; C B Thompson
Journal:  Mol Cell Biol       Date:  1987-12       Impact factor: 4.272
  4 in total

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