Immunogenic and antigenic epitopes of immunoglobulins--V. Reactivity of a panel of monoclonal antibodies with sub-fragments of human Fc gamma and abnormal paraproteins having deletions.

The specificity of a panel of 27 monoclonal antibodies reactive with human Fc gamma has been further defined through reactivity profiles with sub-fragments of Fc gamma and IgG paraproteins having deletions within C gamma 2 or C gamma 3. Antibodies are identified that are directed to discontinuous epitopes requiring native Fc gamma for expression. Other antibodies are reactive with isolated C gamma 2 or C gamma 3 domains. Sub-class specific and sub-class restricted antibodies allow correlation of epitope expression with primary structure.