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Literature DB >> 6192323

Neural tissues express high levels of the cellular src gene product pp60c-src.

Abstract

Chicken embryo tissues were examined for the expression of pp60c-src, the normal cellular homolog of the transforming protein of Rous sarcoma virus. Three assays, including a solid-phase radioimmunoassay, a competitive radioimmunoprecipitation assay, and an immune complex protein kinase assay, were employed. Elevated levels of pp60c-src were detected in lysates from several neural tissues, including brain, retina, and spinal ganglia. Other tissues contained 8- to 10-fold-lower levels of pp60c-src, levels comparable to those found in chicken embryo fibroblasts. Expression of pp60c-src in brain tissues was also shown to vary with the developmental stage of the embryo.

Entities: Gene Species

Mesh：

Substances：

Year: 1983 PMID： 6192323 PMCID： PMC368645 DOI： 10.1128/mcb.3.6.1157-1162.1983

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

28 in total

1. Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.

Authors: S W Kessler
Journal: J Immunol Date: 1975-12 Impact factor: 5.422

2. Animal viruses and embryos.

Authors: J D EBERT; F H WILT
Journal: Q Rev Biol Date: 1960-12 Impact factor: 4.875

3. Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.

Authors: D H Spector; H E Varmus; J M Bishop
Journal: Proc Natl Acad Sci U S A Date: 1978-09 Impact factor: 11.205

4. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

5. Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product.

Authors: M S Collett; J S Brugge; R L Erikson
Journal: Cell Date: 1978-12 Impact factor: 41.582

6. Development of anti-pp60src serum with antigen produced in Escherichia coli.

Authors: T M Gilmer; R L Erikson
Journal: J Virol Date: 1983-01 Impact factor: 5.103

7. 3H-thymidine autoradiographic analysis of telencephalic histogenesis in the chick embryo: II. Dynamics of neuronal migration, displacement, and aggregation.

Authors: H M Tsai; B B Garber; L M Larramendi
Journal: J Comp Neurol Date: 1981-05-10 Impact factor: 3.215

8. Identification of a Rous sarcoma virus transformation-related protein in normal avian and mammalian cells.

Authors: L R Rohrschneider; R N Eisenman; C R Leitch
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

9. Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure.

Authors: J Renart; J Reiser; G R Stark
Journal: Proc Natl Acad Sci U S A Date: 1979-07 Impact factor: 11.205

10. Immunoautoradiographic detection of proteins after electrophoretic transfer from gels to diazo-paper: analysis of adenovirus encoded proteins.

Authors: J Symington; M Green; K Brackmann
Journal: Proc Natl Acad Sci U S A Date: 1981-01 Impact factor: 11.205

91 in total

1. Protooncogene expression identifies a transient columnar organization of the forebrain within the late embryonic ventricular zone.

Authors: J G Johnston; D van der Kooy
Journal: Proc Natl Acad Sci U S A Date: 1989-02 Impact factor: 11.205

2. Drebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex.

Authors: Seika Inoue; Kanehiro Hayashi; Kyota Fujita; Kazuhiko Tagawa; Hitoshi Okazawa; Ken-Ichiro Kubo; Kazunori Nakajima
Journal: J Neurosci Date: 2018-11-30 Impact factor: 6.167

3. Expression of v-src in embryonic neural retina alters cell adhesion, inhibits histogenesis, and prevents induction of glutamine synthetase.

Authors: L Vardimon; L E Fox; R Cohen-Kupiec; L Degenstein; A A Moscona
Journal: Mol Cell Biol Date: 1991-10 Impact factor: 4.272

Neural tissues express high levels of the cellular src gene product pp60c-src.

1. Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.

2. Animal viruses and embryos.

3. Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates.

4. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

5. Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product.

6. Development of anti-pp60src serum with antigen produced in Escherichia coli.

7. 3H-thymidine autoradiographic analysis of telencephalic histogenesis in the chick embryo: II. Dynamics of neuronal migration, displacement, and aggregation.

8. Identification of a Rous sarcoma virus transformation-related protein in normal avian and mammalian cells.

9. Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure.

10. Immunoautoradiographic detection of proteins after electrophoretic transfer from gels to diazo-paper: analysis of adenovirus encoded proteins.

1. Protooncogene expression identifies a transient columnar organization of the forebrain within the late embryonic ventricular zone.

2. Drebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex.

3. Expression of v-src in embryonic neural retina alters cell adhesion, inhibits histogenesis, and prevents induction of glutamine synthetase.

4. Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

5. Characterization of cDNA clones for the human c-yes gene.

6. Lack of induction of neuroretinal cell proliferation by Rous sarcoma virus variants that carry the c-src gene.

7. Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src.

8. Nonmitogenic morphoregulatory action of pp60v-src on multicellular epithelial structures.

Review 9. Control of myogenic differentiation by cellular oncogenes.

Review 10. A molecular view of vertebrate retinal development.