Literature DB >> 6192225

Quantitative evaluation of functional capacity during isoniazid therapy in Huntington's disease.

T Stober, K Schimrigk, G Holzer, B Ziegler.   

Abstract

Eleven patients with Huntington's disease were treated with high doses of isoniazid. In addition to clinical assessment, the functional capacity was evaluated quantitatively. The symptoms of four of the patients showed a marked improvement and their functional capacity increased. The condition of one patient with the rigid form (Westphal's variant) deteriorated, and the remaining six patients showed no change. Patients with prominent mental disturbances appeared to respond best to isoniazid therapy.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6192225     DOI： 10.1007/bf00313552

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  20 in total

1.  Huntington disease: clinical care and evaluation.

Authors:  I Shoulson; S Fahn
Journal:  Neurology       Date:  1979-01       Impact factor: 9.910

2.  The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo.

Authors:  M J Jung; B Lippert; B W Metcalf; P J Schechter; P Böhlen; A Sjoerdsma
Journal:  J Neurochem       Date:  1977-04       Impact factor: 5.372

3.  The relationship between GABA concentrations in brain and cerebrospinal fluid.

Authors:  P Böhlen; S Huot; M G Palfreyman
Journal:  Brain Res       Date:  1979-05-11       Impact factor: 3.252

4.  Huntington's disease: treatment with dipropylacetic acid and gamma-aminobutyric acid.

Authors:  I Shoulson; R Kartzinel; T N Chase
Journal:  Neurology       Date:  1976-01       Impact factor: 9.910

5.  A double-blind clinical trial of isoniazid in Huntington disease.

Authors:  T L Perry; J M Wright; S Hansen; S M Thomas; B M Allan; P A Baird; P A Diewold
Journal:  Neurology       Date:  1982-04       Impact factor: 9.910

6.  GABA metabolism and cerebral protein synthesis.

Authors:  M E Sandoval; R Tapia
Journal:  Brain Res       Date:  1975-10-17       Impact factor: 3.252

7.  gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice.

Authors:  M J Jung; B Lippert; B W Metcalf; P Böhlen; P J Schechter
Journal:  J Neurochem       Date:  1977-11       Impact factor: 5.372

8.  Isoniazid therapy of Huntington disease.

Authors:  T L Perry; J M Wright; S Hansen; P M MacLeod
Journal:  Neurology       Date:  1979-03       Impact factor: 9.910

9.  Valproate sodium in Huntington chorea.

Authors:  I Pearce; K W Heathfield; M J Pearce
Journal:  Arch Neurol       Date:  1977-05

10.  Long-term treatment of juvenile Huntington's chorea with dipropylacetic acid.

Authors:  D S Bachman; I J Butler; G M McKhann
Journal:  Neurology       Date:  1977-02       Impact factor: 9.910
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.