Literature DB >> 6192006

Induction of teratocarcinoma cell differentiation. Effect of the inhibitors of DNA synthesis.

Y Nishimune, A Kume, Y Ogiso, A Matsushiro.   

Abstract

Induction of teratocarcinoma cell (F9) differentiation was studied by using inhibitors of DNA synthesis and several agents known to be differentiation inducers. Inhibition of DNA synthesis induced changes in cell surface marker F9 and stimulated the production of plasminogen activator (PA) in a manner that is dependent upon de novo synthesis of RNA and protein. The results thus indicate close association between inhibition of DNA synthesis and induction of cell differentiation. This approach will be useful in investigating the mechanism of teratocarcinoma cell differentiation.

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Year:  1983        PMID： 6192006     DOI： 10.1016/0014-4827(83)90147-7

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  6 in total

1.  Establishment of composite DNA derived from L factor as a plasmid in mouse embryonal carcinoma (F9) cells.

Authors:  K Nishimori; T Kohda; J Fujiwara; M Oishi
Journal:  Mol Cell Biol       Date:  1988-05       Impact factor: 4.272

2.  Antisense Myc sequences induce differentiation of F9 cells.

Authors:  A E Griep; H Westphal
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

3.  Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3.

Authors:  Y Ido; N Muto; A Inada; J Kohroki; M Mano; T Odani; N Itoh; K Yamamoto; K Tanaka
Journal:  Cell Prolif       Date:  1999-02       Impact factor: 6.831

4.  The kinetics of induction of Hox1.6 and C-jun mRNA during three different ways of inducing differentiation in teratocarcinoma F9 cells.

Authors:  S A Iwai; Y Nishina; M Kosaka; T Sumi; T Doi; M Sakuda; Y Nishimune
Journal:  In Vitro Cell Dev Biol Anim       Date:  1995-06       Impact factor: 2.416

5.  Butyrate selectively activates the metallothionein gene in teratocarcinoma cells and induces hypersensitivity to metal induction.

Authors:  G K Andrews; E D Adamson
Journal:  Nucleic Acids Res       Date:  1987-07-10       Impact factor: 16.971

6.  Induction of in vitro differentiation of mouse embryonal carcinoma (F9) and erythroleukemia (MEL) cells by herbimycin A, an inhibitor of protein phosphorylation.

Authors:  K Kondo; T Watanabe; H Sasaki; Y Uehara; M Oishi
Journal:  J Cell Biol       Date:  1989-07       Impact factor: 10.539
  6 in total

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