Literature DB >> 6191365

Somatostatin 1-28 circulates in human plasma.

F G Baldissera, M A Munoz-Perez, J J Holst.   

Abstract

The gel filtration profile of immunoreactive somatostatin in human plasma in the fasting state is not well established as a consequence of insufficient sensitivity of the combined chromatography and radioimmunoassay procedures usually employed. We here report the gel filtration profiles of plasma samples after somatostatin concentration by batchwise immunoaffinity chromatography. The results clearly and reliably document the presence of a circulating peptide in human plasma with a gel permeation chromatography profile identical to the one of synthetic somatostatin 1-28. Approximately 46% of the total somatostatin-like immunoreactivity in plasma is due to this component.

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Year:  1983        PMID： 6191365     DOI： 10.1016/0167-0115(83)90135-0

Source DB:  PubMed          Journal:  Regul Pept        ISSN： 0167-0115


  11 in total

1.  The alpha cell expresses glucagon-like peptide-2 receptors and glucagon-like peptide-2 stimulates glucagon secretion from the rat pancreas.

Authors:  J de Heer; J Pedersen; C Orskov; J J Holst
Journal:  Diabetologia       Date:  2007-08-04       Impact factor: 10.122

2.  Circulating prosomatostatin-derived peptides. Differential responses to food ingestion.

Authors:  J W Ensinck; E C Laschansky; R E Vogel; D A Simonowitz; B A Roos; B H Francis
Journal:  J Clin Invest       Date:  1989-05       Impact factor: 14.808

3.  Effects of oleic acid and endogenous bile on duodenal secretion of somatostatin in man.

Authors:  O Olsen; J J Holst; O B Schaffalitzky De Muckadell
Journal:  Dig Dis Sci       Date:  1992-07       Impact factor: 3.199

4.  Glicentin 1-61 probably represents a major fraction of glucagon-related peptides in plasma of anaesthetized uraemic pigs.

Authors:  F G Baldissera; J J Holst
Journal:  Diabetologia       Date:  1986-07       Impact factor: 10.122

Review 5.  Somatostatin in acute bleeding oesophageal varices. Pharmacology and rationale for use.

Authors:  E Hanisch; J Doertenbach; K H Usadel
Journal:  Drugs       Date:  1992       Impact factor: 9.546

6.  Effect of vasoactive intestinal polypeptide and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands.

Authors:  P Kirkegaard; P S Olsen; E Nexø; J J Holst; S S Poulsen
Journal:  Gut       Date:  1984-11       Impact factor: 23.059

7.  Circulating somatostatin. Physiological regulator of pancreatic function?

Authors:  K Gyr; C Beglinger; E Köhler; U Trautzl; U Keller; S R Bloom
Journal:  J Clin Invest       Date:  1987-06       Impact factor: 14.808

8.  Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas.

Authors:  J de Heer; C Rasmussen; D H Coy; J J Holst
Journal:  Diabetologia       Date:  2008-09-16       Impact factor: 10.122

9.  Growth hormone releasing factor and somatostatin concentrations in the milk of lactating women.

Authors:  H Werner; P Katz; M Fridkin; Y Koch; S Levine
Journal:  Eur J Pediatr       Date:  1988-04       Impact factor: 3.183

10.  Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors.

Authors:  A H Sparre-Ulrich; L S Hansen; B Svendsen; M Christensen; F K Knop; B Hartmann; J J Holst; M M Rosenkilde
Journal:  Br J Pharmacol       Date:  2015-11-20       Impact factor: 8.739
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