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Literature DB >> 6191267

Axoplasmic transport block reduces ectopic impulse generation in injured peripheral nerves.

Abstract

Afferent fibers ending in nerve end neuromas in rats generate a substantial ectopic discharge and are sensitive to light pressure and to circulating adrenaline. Treatment of the nerve with colchicine or vinblastine at the time of the nerve section resulted in a dose-dependent reduction in the extent of this discharge. Such treatment also reduced neuroma discharge that had already gotten underway.

Entities: Chemical Disease Species

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Year: 1983 PMID： 6191267 DOI： 10.1016/0304-3959(83)90087-8

Source DB: PubMed Journal: Pain ISSN： 0304-3959 Impact factor: 6.961

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Cited

23 in total

1. Peripheral nerve injury activates convergent nociceptive input to dorsal horn neurons from neighboring intact nerve.

Authors: Ryuji Terayama; Yuya Yamamoto; Noriko Kishimoto; Kotaro Maruhama; Masahide Mizutani; Seiji Iida; Tomosada Sugimoto
Journal: Exp Brain Res Date: 2015-01-20 Impact factor: 1.972

2. A₃ adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn.

Authors: Ryuji Terayama; Mitsuyasu Tabata; Kotaro Maruhama; Seiji Iida
Journal: Exp Brain Res Date: 2018-09-11 Impact factor: 1.972

Review 3. The role of sodium channels in chronic pain.

Authors: Simon R Levinson; Songjiang Luo; Michael A Henry
Journal: Muscle Nerve Date: 2012-08 Impact factor: 3.217

4. Detection of sodium channel distribution in rat sciatic nerve following lysophosphatidylcholine-induced demyelination.

Authors: H Meiri; R Steinberg; B Medalion
Journal: J Membr Biol Date: 1986 Impact factor: 1.843

5. Activated microglia contribute to convergent nociceptive inputs to spinal dorsal horn neurons and the development of neuropathic pain.

Authors: Yuya Yamamoto; Ryuji Terayama; Noriko Kishimoto; Kotaro Maruhama; Masahide Mizutani; Seiji Iida; Tomosada Sugimoto
Journal: Neurochem Res Date: 2015-03-18 Impact factor: 3.996

6. Possible involvement of convergent nociceptive input to medullary dorsal horn neurons in intraoral hyperalgesia following peripheral nerve injury.

Authors: Ryuji Terayama; Hiroki Tsuchiya; Shinji Omura; Kotaro Maruhama; Masahide Mizutani; Seiji Iida; Tomosada Sugimoto
Journal: Cell Mol Neurobiol Date: 2014-11-19 Impact factor: 5.046

Axoplasmic transport block reduces ectopic impulse generation in injured peripheral nerves.

1. Peripheral nerve injury activates convergent nociceptive input to dorsal horn neurons from neighboring intact nerve.

2. A₃ adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn.

Review 3. The role of sodium channels in chronic pain.

4. Detection of sodium channel distribution in rat sciatic nerve following lysophosphatidylcholine-induced demyelination.

5. Activated microglia contribute to convergent nociceptive inputs to spinal dorsal horn neurons and the development of neuropathic pain.

6. Possible involvement of convergent nociceptive input to medullary dorsal horn neurons in intraoral hyperalgesia following peripheral nerve injury.

7. Convergent nociceptive input to spinal dorsal horn neurons after peripheral nerve injury.

8. Inflammatory mediators sensitize acutely axotomized nerve fibers to mechanical stimulation in the rat.

9. Mechanical sensitivity of regenerating myelinated skin and muscle afferents in the cat.

10. Disruption of axoplasmic transport induces mechanical sensitivity in intact rat C-fibre nociceptor axons.