Literature DB >> 619104

Determination of ionization constants in mixed aqueous solvents of varying composition by a single titration.

J Peeters.   

Abstract

A potentiometric titration method is proposed in which only one titration is necessary to obtain pK'a values for different solvent compositions. The method allows the results to be extrapolated to the value for pure water. Examples are given, and the advantages and disadvantages of the method are discussed.

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Year:  1978        PMID： 619104     DOI： 10.1002/jps.2600670137

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  3 in total

1.  Formation of stable nanocarriers by in situ ion pairing during block-copolymer-directed rapid precipitation.

Authors:  Nathalie M Pinkerton; Arnaud Grandeury; Andreas Fisch; Jörg Brozio; Bernd U Riebesehl; Robert K Prud'homme
Journal:  Mol Pharm       Date:  2012-12-24       Impact factor: 4.939

2.  Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations.

Authors:  Ann Marie Kaukonen; Ben J Boyd; Christopher J H Porter; William N Charman
Journal:  Pharm Res       Date:  2004-02       Impact factor: 4.200

3.  SNEDDS Containing Poorly Water Soluble Cinnarizine; Development and in Vitro Characterization of Dispersion, Digestion and Solubilization.

Authors:  Anne T Larsen; Anayo Ogbonna; Ragheb Abu-Rmaileh; Bertil Abrahamsson; Jesper Ostergaard; Anette Müllertz
Journal:  Pharmaceutics       Date:  2012-12-14       Impact factor: 6.321
  3 in total

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