Literature DB >> 6190667

Activation of human ribosomal genes by 5-azacytidine.

M Ferraro, P Lavia.   

Abstract

Cultured human fibroblasts were exposed to 5-azacytidine which inhibits methylation of newly synthesized DNA. A significant increase in the mean number of Ag-stained active nucleolus organizers has been observed in treated cells. This suggests that DNA methylation is involved in modulation of human rRNA synthesis.

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Year:  1983        PMID： 6190667     DOI： 10.1016/0014-4827(83)90024-1

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  11 in total

1.  A molecular deletion of distal chromosome 4p in two families with a satellited chromosome 4 lacking the Wolf-Hirschhorn syndrome phenotype.

Authors:  L L Estabrooks; A N Lamb; H N Kirkman; N P Callanan; K W Rao
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

2.  Methylation status of ribosomal RNA gene clusters in the flow-sorted human acrocentric chromosomes.

Authors:  K Kawasaki; S Minoshima; J Kudoh; R Fukuyama; N Shimizu
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

3.  Inheritance of ribosomal gene activity and level of DNA methylation of individual gene clusters in a three generation family.

Authors:  A de Capoa; C Aleixandre; M P Felli; L Ravenna; M A Costantino; P Giancotti; O Vicenti; I Poggesi; C Grappelli; D A Miller
Journal:  Hum Genet       Date:  1991-12       Impact factor: 4.132

4.  Differential gene activity visualized on sister chromatids after replication in the presence of 5-azacytidine.

Authors:  M Ferraro; P Lavia
Journal:  Chromosoma       Date:  1985       Impact factor: 4.316

5.  Use of nucleolar organiser regions (NOR's) for diagnosing gynaecological neoplasia.

Authors:  A J Wood
Journal:  J Clin Pathol       Date:  1989-07       Impact factor: 3.411

6.  Variability of human rRNA genes: inheritance and nonrandom chromosomal distribution of structural variants of nontranscribed spacer sequences.

Authors:  I V Garkavtsev; T G Tsvetkova; N A Yegolina; A V Gudkov
Journal:  Hum Genet       Date:  1988-12       Impact factor: 4.132

7.  Ribosomal DNA clusters in pulsed-field gel electrophoretic analysis of human acrocentric chromosomes.

Authors:  A K Srivastava; Y Hagino; D Schlessinger
Journal:  Mamm Genome       Date:  1993       Impact factor: 2.957

8.  Differential activation of the hprt gene on the inactive X chromosome in primary and transformed Chinese hamster cells.

Authors:  S G Grant; R G Worton
Journal:  Mol Cell Biol       Date:  1989-04       Impact factor: 4.272

9.  Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation.

Authors:  Ignacio E Schor; Ana Fiszbein; Ezequiel Petrillo; Alberto R Kornblihtt
Journal:  EMBO J       Date:  2013-07-26       Impact factor: 11.598

Review 10.  Nucleolar organiser regions in pathology.

Authors:  M J Egan; J Crocker
Journal:  Br J Cancer       Date:  1992-01       Impact factor: 7.640
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