| Literature DB >> 6190661 |
F Rosa, P P Le Bouteiller, A Abadie, Z Mishal, F A Lemonnier, D Bourrel, M Lamotte, J Kalil, B Jordan, M Fellous.
Abstract
In human cells treated with interferon, there is an increase in the amount of HLA-A, B, C mRNA and, to a lower extent, membrane-bound antigen. However, the mechanism of this mRNA enhancement is still unknown. Using mouse L cells transfected with a unique class I HLA gene, we were able to show that both the related HLA mRNA and protein are increased after murine but not human interferon treatment. Moreover, the discrepancy between interferon-directed HLA mRNA and protein enhancement is also observed. The mouse transfected cells allowed us to study more precisely the origin of this discrepancy.Entities:
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Year: 1983 PMID: 6190661 DOI: 10.1002/eji.1830130612
Source DB: PubMed Journal: Eur J Immunol ISSN: 0014-2980 Impact factor: 5.532