Literature DB >> 6189738

Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes.

M B Castillo, M D Gonzalez, G Burton, C P Lantos, A Roldán.   

Abstract

A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11 beta-ol-3,20-dione and pregna-1,4-diene-11 beta-ol-3,20-dione. In contrast, no dissociation of these effects was found with the typical glucocorticoids cortisol and corticosterone, nor with their 1,4-diene analogs under the same conditions.

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Year:  1983        PMID： 6189738     DOI： 10.1007/bf01971126

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  HORMONAL CONTROL OF LYMPHATIC STRUCTURE AND FUNCTION.

Authors:  T F DOUGHERTY; M L BERLINER; G L SCHNEEBELI; D L BERLINER
Journal:  Ann N Y Acad Sci       Date:  1964-02-28       Impact factor: 5.691

2.  EFFECT OF GLUCOCORTICOIDS IN VIVO AND IN VITRO ON NET GLUCOSE UPTAKE AND AMINO ACID INCORPORATION BY RAT-THYMUS CELLS.

Authors:  Y MORITA; A MUNCK
Journal:  Biochim Biophys Acta       Date:  1964-10-09

3.  An in vitro effect of physiological levels of cortisol and related steroids on the structural integrity of the nucleus in rat thymic lymphocytes as measured by resistance to lysis.

Authors:  S J Giddings; D A Young
Journal:  J Steroid Biochem       Date:  1974-10       Impact factor: 4.292

Review 4.  Corticosteroid-induced changes in phospholipid membranes as mediators of their action.

Authors:  D H Nelson
Journal:  Endocr Rev       Date:  1980       Impact factor: 19.871

5.  Glucocorticoid-induced cell-size changes and nuclear fragility in rat thymocytes.

Authors:  N Thomas; P A Bell
Journal:  Mol Cell Endocrinol       Date:  1981-04       Impact factor: 4.102

6.  Steroid specificity of the glucocorticoid inhibition of amino acid transport in rat hepatoma cells.

Authors:  T D Gelehrter; R A McDonald
Journal:  Endocrinology       Date:  1981-08       Impact factor: 4.736

7.  Inhibition of thymocyte RNA synthesis by natural adrenal steroids and their 1,4-diene analogs. Structure-activity correlations using 13C-n.m.r. spectroscopy.

Authors:  A Roldán; G Burton; M B Castillo; M C Damasco; C P Lantos
Journal:  J Steroid Biochem       Date:  1981-12       Impact factor: 4.292
  7 in total

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