Literature DB >> 6189731

Substance P mediates atropine-sensitive response of guinea-pig ileum to serotonin.

L A Chahl.   

Abstract

The action of serotonin (5HT) was investigated on guinea-pig isolated ileum. Low concentrations of 5HT (10(-8) - 2.5 x 10(-7) mol x 1(-1)) produced contractile responses which were abolished by atropine and by methionine enkephalin but not by methysergide. Higher concentrations of 5HT (5 x 10(-7) - 5 x 10(-6) mol x 1(-1)) produced contractions which were inhibited by methysergide. The atropine-sensitive response was also abolished following desensitization of preparations to substance P and by the substance P antagonist [D-Pro2,D-Phe7,D-Trp9]SP. It was concluded that the atropine-sensitive response to 5HT is mediated by substance P.

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Year:  1983        PMID： 6189731     DOI： 10.1016/0014-2999(83)90090-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

1.  Pharmacological characterization of the 5-HT receptor-mediated contraction in the mouse isolated ileum.

Authors:  B R Tuladhar; M D Womack; R J Naylor
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

2.  Characterization of the 5-hydroxytryptamine receptors mediating contraction in the intestine of Suncus murinus.

Authors:  F A Javid; R J Naylor
Journal:  Br J Pharmacol       Date:  1999-08       Impact factor: 8.739

3.  Altered respiratory activity and respiratory regulations in adult monoamine oxidase A-deficient mice.

Authors:  H Burnet; M Bevengut; F Chakri; C Bou-Flores; P Coulon; S Gaytan; R Pasaro; G Hilaire
Journal:  J Neurosci       Date:  2001-07-15       Impact factor: 6.167

4.  Mu and kappa opioid receptor modulation of 5-HT3 and NK-3 receptor-evoked release of acetylcholine from the guinea-pig ileum myenteric plexus.

Authors:  A J Fox; I K Morton
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-07       Impact factor: 3.000

5.  5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum.

Authors:  D A Craig; R M Eglen; L K Walsh; L A Perkins; R L Whiting; D E Clarke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-07       Impact factor: 3.000

6.  Activation of 5-HT3 receptors in the rat and mouse intestinal tract: a comparative study.

Authors:  Navinisha Chetty; Helen R Irving; Ian M Coupar
Journal:  Br J Pharmacol       Date:  2006-06-12       Impact factor: 8.739

7.  Post-tetanic potentiation at the nerve-muscle junction in the longitudinal muscle of the guinea-pig ileum. Possible role of substance P.

Authors:  O Kadlec; K Masek; I Seferna
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-06       Impact factor: 3.000

8.  Innervation of the muscularis mucosae of canine proximal colon.

Authors:  F Angel; V L Go; J H Szurszewski
Journal:  J Physiol       Date:  1984-12       Impact factor: 5.182

9.  Contracture of guinea-pig ileum on withdrawal of methionine5-enkephalin is mediated by substance P.

Authors:  L A Chahl
Journal:  Br J Pharmacol       Date:  1983-12       Impact factor: 8.739

10.  Increased gut cholinergic activity and antagonism of 5-hydroxytryptamine M-receptors by BRL 24924: potential clinical importance of BRL 24924.

Authors:  G J Sanger
Journal:  Br J Pharmacol       Date:  1987-05       Impact factor: 8.739
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