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Literature DB >> 6189128

Unusual human interferons produced by virus-infected amniotic membranes.

P Duc-Goiran, B Robert-Galliot, T Chudzio, C Chany.

Abstract

Interferon (IFN) induced in the human amniotic membrane contains at least five different molecular species, as shown by analysis in NaDodSO4/polyacrylamide gels after heating and under reducing conditions. Three of the IFN components reported here--migrating at 26, 43, and 80 kilodaltons--are of unusual antigenic structure because they are neutralized to about the same extent by anti-IFN-alpha and anti-IFN-beta antibodies. The 15- to 17-kilodalton species belongs to the IFN-alpha group, while the 21- to 22-kilodalton species, the most frequently detected major peak, is IFN-beta. In addition to their unusual size and antigenic structure, these IFNs could play a role during embryonic development and in the immune tolerance of the mother with regard to the fetus.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Epitopes
Interferons

Year: 1983 PMID： 6189128 PMCID： PMC393880 DOI： 10.1073/pnas.80.9.2628

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

24 in total

1. Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells.

Authors: K PAUCKER; K CANTELL; W HENLE
Journal: Virology Date: 1962-06 Impact factor: 3.616

2. [Study of the mechanism of the refractory state of interferon producing cells, after repeated induction].

Authors: C Chany; M Vignal
Journal: C R Acad Hebd Seances Acad Sci D Date: 1968-11-18

3. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

4. Interferon effect on collagen and fibronectin distribution in the extracellular matrix of murine sarcoma virus-transformed cells.

Authors: J Gerfaux; S Rousset; F Chany-Fournier; C Chany
Journal: Cancer Res Date: 1981-09 Impact factor: 12.701

Unusual human interferons produced by virus-infected amniotic membranes.

1. Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells.

2. [Study of the mechanism of the refractory state of interferon producing cells, after repeated induction].

3. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

4. Interferon effect on collagen and fibronectin distribution in the extracellular matrix of murine sarcoma virus-transformed cells.

5. Interferon inhibits dimethyl sulphoxide-induced erythroid differentiation of Friend leukaemia cells.

6. Human leukocyte interferon: relationship between molecular structure and species specificity.

7. Identification of an interferon in murine placentas.

8. Protective effect of interferon on target cells exposed to cellular cytotoxicity.

9. Interferon effect on cytolytic T lymphocytes in a single cycle assay.

10. Reorganization of the cytoskeleton by interferon in MSV-transformed cells.

1. Antitumor therapy based on the use of an immune modulator, arginine butyrate and interferon.

2. A neutrophil-derived antiviral protein: induction requirements and biological properties.

3. Unusual apparently constitutive interferons and antagonists in human placental blood.