Literature DB >> 6188804

The 5-hydroxytryptamine antagonist ketanserin inhibits the vasoconstrictor activity of per-operative CSF, from subarachnoid haemorrhage patients, on isolated tissues.

P C Tagari, A H Kaye, P J Teddy, M Schachter, C B Adams, D J Boullin.   

Abstract

Peri-aneurysmal CSF was obtained at operation from 13 patients with subarachnoid haemorrhage from ruptured intracranial aneurysms. The 5-hydroxytryptamine antagonist ketanserin inhibited contractions of isolated human intracranial arteries, elicited by this CSF. The presence of 5-HT in CSF was confirmed by high performance liquid chromatography. The use of ketanserin in the therapy of postoperative cerebral vasospasm is discussed.

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Year:  1983        PMID： 6188804      PMCID： PMC1027327          DOI： 10.1136/jnnp.46.3.214

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  19 in total

1.  DEMONSTRATION OF SUBSTANCES CAPABLE OF CONTRACTING SMOOTH MUSCLE IN THE HAEMATOMA FLUID FROM CERTAIN CASES OF RUPTURED CEREBRAL ANEURYSM.

Authors:  M BUCKELL
Journal:  J Neurol Neurosurg Psychiatry       Date:  1964-06       Impact factor: 10.154

2.  Experimental study on the genesis of cerebral vasospasm.

Authors:  R P White; A A Hagen; H Morgan; W N Dawson; J T Robertson
Journal:  Stroke       Date:  1975 Jan-Feb       Impact factor: 7.914

3.  Aetiology of cerebral arterial spasm following subarachnoid haemorrhage: evidence against a major involvement of 5-hydroxy-tryptamine in the production of acute spasm.

Authors:  D J Boullin; G H Du Boulay; A T Rogers
Journal:  Br J Clin Pharmacol       Date:  1978-09       Impact factor: 4.335

Review 4.  [Cerebral vasospasm in subarachnoid hemorrhage--with reference to its mechanism (author's transl)].

Authors:  S Ishii; T Nonaka
Journal:  No To Shinkei       Date:  1977-08

5.  Cerebral arterial spasm. Modification by inhibition of platelet function.

Authors:  N T Zervas; A Kuwayama; C B Rosoff; E W Salzman
Journal:  Arch Neurol       Date:  1973-06

6.  Cerebral circulatory and metabolic effects of 5-hydroxytryptamine in anesthetized baboons.

Authors:  M A Harper; E T MacKenzie
Journal:  J Physiol       Date:  1977-10       Impact factor: 5.182

7.  Surgical risk as related to time of intervention in the repair of intracranial aneurysms.

Authors:  W E Hunt; R M Hess
Journal:  J Neurosurg       Date:  1968-01       Impact factor: 5.115

8.  Comparative effects of four migraine prophylactic drugs on an isolated extracranial artery.

Authors:  J R Fozard
Journal:  Eur J Pharmacol       Date:  1976-03       Impact factor: 4.432

9.  Evidence for the presence of a vasoactive substance (possibly involved in the aetiology of cerebral arterial spasm) in cerebrospinal fluid from patients with subarachnoid haemorrhage.

Authors:  D J Boullin; J Mohan; D G Grahame-Smith
Journal:  J Neurol Neurosurg Psychiatry       Date:  1976-08       Impact factor: 10.154

10.  Cerebral vasospasm with ruptured saccular aneurysm--the clinical manifestations.

Authors:  C M Fisher; G H Roberson; R G Ojemann
Journal:  Neurosurgery       Date:  1977 Nov-Dec       Impact factor: 4.654
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  1 in total

1.  Effect of ketanserin on 5-hydroxytryptamine-induced constriction in isolated, perfused canine basilar arteries exposed to blood.

Authors:  T Tsuji; D A Cook
Journal:  Acta Neurochir (Wien)       Date:  1996       Impact factor: 2.216
  1 in total

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