Literature DB >> 6188688

Biochemical characterization of Ia antigens encoded by the RT1.B and RT1.D loci in the rat MHC.

E P Blankenhorn, F W Symington, D V Cramer.   

Abstract

Ia antigens in rats are genetically associated with typical MHC-linked immune response (Ir) genes. One rat Ir gene (IR-GLT) has recently been mapped to the RT1.D locus in a rat MHC recombinant, WRC. We have studied the expression of Ia antigenic determinants in WRC and its parental strains BN and WRA using a panel of monoclonal antibodies. Our results suggest that the inheritance of IR-GLT corresponds with the inheritance of I-E-like, but not I-A-like, antigens in the WRC rat. These observations were confirmed when WRC I-E-like antigens were analyzed by two-dimensional gel electrophoresis. We propose that RT1.D shares both functional and antigenic homologies with the mouse I-E subregion.

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Year:  1983        PMID： 6188688     DOI： 10.1007/bf00696871

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  25 in total

Review 1.  Properties of rat anti-MHC antibodies produced by cloned rat-mouse hybridomas.

Authors:  T J McKearn; F W Fitch; D E Smilek; M Sarmiento; F P Stuart
Journal:  Immunol Rev       Date:  1979       Impact factor: 12.988

2.  Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens.

Authors:  V T Oi; P P Jones; J W Goding; L A Herzenberg; L A Herzenberg
Journal:  Curr Top Microbiol Immunol       Date:  1978       Impact factor: 4.291

3.  A monoclonal antibody detecting an Ia specificity mapping in the I-A or I-E subregion.

Authors:  F W Symington; J Sprent
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

4.  A biological role for the major histocompatibility antigens.

Authors:  P C Doherty; R M Zinkernagel
Journal:  Lancet       Date:  1975-06-28       Impact factor: 79.321

Review 5.  Ia antigens as restriction molecules in Ir-gene controlled T-cell proliferation.

Authors:  Z A Nagy; C N Baxevanis; N Ishii; J Klein
Journal:  Immunol Rev       Date:  1981       Impact factor: 12.988

6.  Genetic control of specific immune responses and immune suppressions by I-region genes.

Authors:  B Benacerraf; M E Dorf
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

7.  Microsequence analysis of Ia antigens from three strains of rats.

Authors:  J M Cecka; E P Blankenhorn; D Götze; L Hood
Journal:  Eur J Immunol       Date:  1980-02       Impact factor: 5.532

8.  Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

Authors:  K Ozato; N Mayer; D H Sachs
Journal:  J Immunol       Date:  1980-02       Impact factor: 5.422

9.  Two-gene control of the expression of a murine Ia antigen.

Authors:  P P Jones; D B Murphy; H O McDevitt
Journal:  J Exp Med       Date:  1978-10-01       Impact factor: 14.307

10.  Monoclonal rat anti-major histocompatibility complex antibodies display specificity for rat, mouse, and human target cells.

Authors:  D E Smilek; H C Boyd; D B Wilson; C M Zmijewski; F W Fitch; T J McKearn
Journal:  J Exp Med       Date:  1980-05-01       Impact factor: 14.307
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  13 in total

1.  Comparison of rat MHC class I antigens by peptide mapping.

Authors:  D N Misra; H W Kunz; A L Cortese Hassett; T J Gill
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

2.  Orientation of the loci encoding RT1.B polypeptides in the major histocompatibility complex of the rat.

Authors:  E P Blankenhorn; D V Cramer
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

3.  Class I and class II restriction pattern polymorphisms associated with independently derived RT1 haplotypes in inbred rats.

Authors:  P J Wettstein; S Faas; D A Buck
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

4.  Polymorphism and mapping of the class II genes in the rat: RT1.B, RT1.D, and RT1.H, a new DP-like region.

Authors:  J W Watters; J D Locker; H W Kunz; T J Gill
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

5.  DNA sequence analysis of a rat RT1 class II A beta gene.

Authors:  S J Eccles; W R McMaster
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

6.  Isolation and characterization of a cDNA clone for the MHC class II chain RT1.Du alpha of the diabetic BB rat.

Authors:  E W Holowachuk
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

Review 7.  The immunology of experimental liver transplantation in the rat.

Authors:  N Kamada
Journal:  Immunology       Date:  1985-07       Impact factor: 7.397

8.  In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products.

Authors:  C Boitard; S Michie; P Serrurier; G W Butcher; A P Larkins; H O McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

9.  DNA sequence analysis of the rat RT1.B alpha gene.

Authors:  P A Barran; W R McMaster
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

10.  Cim: an MHC class II-linked allelism affecting the antigenicity of a classical class I molecule for T lymphocytes.

Authors:  A M Livingstone; S J Powis; E Günther; D V Cramer; J C Howard; G W Butcher
Journal:  Immunogenetics       Date:  1991       Impact factor: 2.846
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