Literature DB >> 6188620

Tissue selectivity of substance P alkyl esters: suggesting multiple receptors.

S P Watson, B E Sandberg, M R Hanley, L L Iversen.   

Abstract

Previous studies from this laboratory suggested that two subtypes of substance P receptor may exist, based on the observations that substance P and related peptides did not exhibit complete cross-desensitisation on guinea-pig ileum, and that two distinct rank orders of potency of tachykinins were observed in various test systems. The present study has added support to this hypothesis by extending the screening of tachykinins to further bioassays and by testing novel analogues. In particular, C-terminal alkyl esters of substance P were found to exhibit a high degree of selectivity to one putative receptor subtype. The synthesis of the alkyl esters by esterification of substance P free acid is described.

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Year:  1983        PMID： 6188620     DOI： 10.1016/0014-2999(83)90052-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  28 in total

1.  Pharmacological specificity of novel, synthetic, cyclic peptides as antagonists at tachykinin receptors.

Authors:  A T McKnight; J J Maguire; N J Elliott; A E Fletcher; A C Foster; R Tridgett; B J Williams; J Longmore; L L Iversen
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

2.  In vivo and in vitro actions of mammalian tachykinins.

Authors:  U Holzer-Petsche; E Schimek; R Amann; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-08       Impact factor: 3.000

3.  The action of substance P methyl ester on cochlear potentials in the guinea pig.

Authors:  K Nario; I Kitano; N Mori; T Matsunaga
Journal:  Eur Arch Otorhinolaryngol       Date:  1995       Impact factor: 2.503

4.  Regional differences in the effects of capsaicin and tachykinins on motor activity and vascular permeability of the rat lower urinary tract.

Authors:  C A Maggi; P Santicioli; L Abelli; M Parlani; M Capasso; B Conte; S Giuliani; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-06       Impact factor: 3.000

5.  Comparison of the effects of epithelium removal and of an enkephalinase inhibitor on the neurokinin-induced contractions of guinea-pig isolated trachea.

Authors:  P Devillier; C Advenier; G Drapeau; J Marsac; D Regoli
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

6.  Two modes of regulation of the phospholipase C-linked substance-P receptor in rat parotid acinar cells.

Authors:  H Sugiya; J F Obie; J W Putney
Journal:  Biochem J       Date:  1988-07-15       Impact factor: 3.857

7.  Receptors for neurotransmitters in opossum oesophagus muscularis mucosa.

Authors:  E E Daniel; J Jury; K H Robotham
Journal:  Br J Pharmacol       Date:  1986-07       Impact factor: 8.739

8.  Tachykinin receptors mediating responses to sensory nerve stimulation and exogenous tachykinins and analogues in the rabbit isolated iris sphincter.

Authors:  J M Hall; D Mitchell; I K Morton
Journal:  Br J Pharmacol       Date:  1993-08       Impact factor: 8.739

9.  Characterization of the receptor mediating relaxation to substance P in canine middle cerebral artery: no evidence for involvement of substance P in neurogenically mediated relaxation.

Authors:  C M Stubbs; G J Waldron; H E Connor; W Feniuk
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

10.  A pharmacological study of NK1 and NK2 tachykinin receptor characteristics in the rat isolated urinary bladder.

Authors:  J M Hall; J M Flowers; I K Morton
Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739
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