Literature DB >> 6188020

Radioimmunoassay of substance P and its stability in tissue.

G P McGregor, S R Bloom.   

Abstract

A sensitive and specific radioimmunoassay for substance P has been developed and its full characterisation is described. The assay was used to investigate the stability of substance P in tissue in order to establish the optimal conditions of tissue storage for maximal recovery of the peptide. The results indicate unexpected post-mortem changes in tissue substance P content and suggests its existence in at least two separate pools, which differ in their susceptibility to degradation. These results highlight the need for careful consideration of both extraction technique and assay characteristics in radioimmunological investigations of substance P.

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Substances：

Year:  1983        PMID： 6188020     DOI： 10.1016/0024-3205(83)90211-4

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  11 in total

1.  Regulatory peptides in the respiratory tract of Macaca fascicularis.

Authors:  M A Ghatei; D R Springall; I M Richards; J A Oostveen; R L Griffin; A Cadieux; J M Polak; S R Bloom
Journal:  Thorax       Date:  1987-06       Impact factor: 9.139

Review 2.  Aspects of measurement and analysis of regulatory peptides.

Authors:  J M Burrin; L O Uttenthal; G P McGregor; S R Bloom
Journal:  Experientia       Date:  1987-07-15

3.  Measurement of substance P and met-enkephalin in the serum of violent death victims.

Authors:  Lawrence Quarino; Robert C Shaler
Journal:  Forensic Sci Med Pathol       Date:  2006-12       Impact factor: 2.007

4.  Substance P concentration and history of headache in relation to postlumbar puncture headache: towards prevention.

Authors:  J W Clark; G D Solomon; P D Senanayake; C Gallagher
Journal:  J Neurol Neurosurg Psychiatry       Date:  1996-06       Impact factor: 10.154

5.  Neuropeptides in neurological tumours.

Authors:  J M Allen; N R Hoyle; J C Yeats; M A Ghatei; D G Thomas; S R Bloom
Journal:  J Neurooncol       Date:  1985       Impact factor: 4.130

6.  Haemodynamics of pelvic nerve induced penile erection in the dog: possible mediation by vasoactive intestinal polypeptide.

Authors:  P O Andersson; S R Bloom; S Mellander
Journal:  J Physiol       Date:  1984-05       Impact factor: 5.182

7.  Effects of stimulating the sympathetic innervation in bursts on submandibular vascular and secretory function in cats.

Authors:  S R Bloom; A V Edwards; J R Garrett
Journal:  J Physiol       Date:  1987-12       Impact factor: 5.182

8.  Occurrence, distribution and origin of peptide-containing nerves of guinea-pig and rat male genitalia and the effects of denervation on sperm characteristics.

Authors:  T L Carvalho; N P Hodson; M A Blank; P F Watson; P K Mulderry; A E Bishop; J Gu; S R Bloom; J M Polak
Journal:  J Anat       Date:  1986-12       Impact factor: 2.610

Review 9.  Neuropeptide substance P and the immune response.

Authors:  Alireza Mashaghi; Anna Marmalidou; Mohsen Tehrani; Peter M Grace; Charalabos Pothoulakis; Reza Dana
Journal:  Cell Mol Life Sci       Date:  2016-06-17       Impact factor: 9.261

10.  Overexpression of Substance P in pig airways increases MUC5AC through an NF-kβ pathway.

Authors:  Mariana Sponchiado; Yan-Shin Liao; Kalina R Atanasova; Emily N Collins; Veronica Schurmann; Laura Bravo; Leah R Reznikov
Journal:  Physiol Rep       Date:  2021-02
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